Evidence supporting the use of: Alpha-Lipoic Acid
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha-Lipoic Acid (ALA) is an antioxidant that has been studied for a variety of neurological and metabolic conditions. Regarding migraines, there is some emerging scientific evidence suggesting a potential benefit, though the data are still limited and not robust enough for strong clinical recommendations. A few small randomized controlled trials have evaluated the efficacy of ALA in migraine prophylaxis. For example, a double-blind, placebo-controlled study published in 2007 found that supplementation with ALA (600 mg/day) for three months significantly reduced the frequency and severity of migraine attacks compared to placebo. Another trial indicated that ALA could improve endothelial function, which is thought to play a role in migraine pathophysiology.

The suggested mechanisms include ALA’s antioxidant properties, improvement of mitochondrial function, and enhancement of nitric oxide-mediated vasodilation, all of which may be relevant since oxidative stress and vascular dysfunction are implicated in migraine pathogenesis. However, these studies are generally small in size and of short duration, and larger, more rigorous trials are needed to confirm these findings.

In summary, while there is some scientific evidence supporting the use of Alpha-Lipoic Acid for migraine prevention, it is preliminary, and ALA should not be considered a first-line therapy. The strength of evidence is moderate at best, justifying a rating of 2 on a 0-5 scale.

More about Alpha-Lipoic Acid
More about Migraine

Other ingredients used for Migraine

5-Hydroxytryptophan (5-HTP)
alpha-linolenic acid (ALA)
ashwagandha
bergamot
beta caryophyllene
black tea
Indian frankincense
bupleurum falcatum
Chinese salvia root
coenzyme Q10 (CoQ10)
turmeric
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
feverfew
fish oil
ginger
ginkgo biloba
gooseberry
gotu kola
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
luteolin
magnesium
melatonin
moringa
niacin (vitamin B3)
omega-3 fatty acids
Peppermint
phytocannabinoids
pine bark
purple butterbur root
riboflavin (vitamin B2)
specialized pro-resolving mediators (SPMs)
Almond fruit
ubiquinol
valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
zinc
atractylodes
blackboard tree
swertia
Szechuan lovage
chrysanthemum
soursop
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
Apple Cider Vinegar
Albizia
Alpha-Lipoic Acid
Atractylone
Betony
Black Seed
Baikal Skullcap
Beta-hydroxybutyrate
Blepharis
Balsam
Banyan
Brahmi
Butterbur
Bifidobacteria
Black Hellebore
Chinese Silkvine
Crocin
Creatine
Cannabidiol
Corydalis
Carthamus
cola nut
Docosahexaenoic Acid
Danshen
Eicosapentaenoic Acid
Folic Acid
Flavin mononucleotide
Ficus religiosa
Fish
Flavanones
Ficus simplicissima
Frankincense
Goldthread
Gelsemium
Ginkgolides
Ginkgoside
Hellebore
iridoids
Ketone Salts
Kuding tea
lemon balm
Lesser speargrass
Little ironweed
Linalool
Mesua
Methylxanthine
Meadowsweet
Nardostachys
Night jessamine
Osthole
Puerarin
Petasines
Phthalides
Paeoniflorin
Pycnogenol
Polygonum
Palmitoylethanolamide (PEA)
Rue
Rubus
Rauvolfia
Rubiaceae
Spikenard
Sensitive Plant
Salmon Oil
Sandalwood
Scabrous Gentian
Uncaria
Withanolides
Xanthine
Xanthophyll
Xanthone
Yuzu
Zingerone

Products containing Alpha-Lipoic Acid

We currently have no products on Vitabase that contain this ingredient.