Evidence supporting the use of: Beta Hydroxybutyrate
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Beta hydroxybutyrate (BHB), a primary ketone body produced during states of ketosis, has garnered scientific interest as a potential adjunct for migraine management. The rationale stems from observations that ketogenic diets—characterized by elevated BHB—can reduce migraine frequency and severity in some patients. Preliminary studies propose several mechanisms: BHB may stabilize neuronal excitability, improve mitochondrial function, reduce neuroinflammation, and modulate glutamate activity, all of which are implicated in migraine pathophysiology.

Clinical evidence remains limited but promising. Small pilot studies and case reports have shown that ketogenic diets, which raise circulating BHB, can lead to meaningful reductions in migraine days and intensity. However, these studies often lack controls and involve dietary changes, making it difficult to attribute effects solely to BHB. More recently, exogenous BHB supplements have been explored. Early animal studies and pilot human trials suggest they may mimic the beneficial effects of ketogenic diets, but robust, placebo-controlled human data are scarce.

In summary, while there is a scientific rationale and some preliminary evidence supporting BHB’s use in migraine, high-quality clinical trials are needed to validate efficacy and determine optimal dosing. Current evidence rates as modest (2/5), reflecting a foundation in theory and early research rather than established clinical practice.

More about Beta Hydroxybutyrate
More about Migraine

Other ingredients used for Migraine

5-Hydroxytryptophan (5-HTP)
alpha-linolenic acid (ALA)
ashwagandha
bergamot
beta caryophyllene
black tea
Indian frankincense
bupleurum falcatum
Chinese salvia root
coenzyme Q10 (CoQ10)
turmeric
curcumin
DHA (docosahexaenoic acid)
EPA (eicosapentaenoic acid)
feverfew
fish oil
ginger
ginkgo biloba
gooseberry
gotu kola
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
luteolin
magnesium
Melatonin
Moringa
Niacin (vitamin B3)
omega-3 fatty acids
Peppermint
phytocannabinoids
pine bark
purple butterbur root
riboflavin (vitamin B2)
specialized pro-resolving mediators (SPMs)
Almond fruit
ubiquinol
Valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
Zinc
atractylodes
blackboard tree
Swertia
Szechuan lovage
chrysanthemum
soursop
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
apple cider vinegar
Albizia
alpha-lipoic acid
atractylone
betony
black seed
Baikal Skullcap
beta-hydroxybutyrate
Blepharis
balsam
banyan
brahmi
butterbur
Bifidobacteria
Black Hellebore
Chinese silkvine
crocin
creatine
cannabidiol
Corydalis
Carthamus
cola nut
docosahexaenoic Acid
danshen
eicosapentaenoic acid
folic acid
flavin mononucleotide
Ficus religiosa
fish
flavanones
Ficus simplicissima
frankincense
goldthread
Gelsemium
ginkgolides
Ginkgoside
Hellebore
iridoids
ketone salts
kuding tea
lemon balm
Lesser speargrass
little ironweed
linalool
Mesua
Methylxanthine
Meadowsweet
Nardostachys
Night jessamine
Osthole
Puerarin
Petasines
Phthalides
paeoniflorin
Pycnogenol
Polygonum
Palmitoylethanolamide (PEA)
rue
Rubus
Rauvolfia
Rubiaceae
Spikenard
Sensitive Plant
Salmon Oil
Sandalwood
Scabrous Gentian
Uncaria
Withanolides
Xanthine
Xanthophyll
Xanthone
Yuzu
Zingerone

Products containing Beta Hydroxybutyrate

We currently have no products on Vitabase that contain this ingredient.