Evidence supporting the use of: Cannabidiol
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Cannabidiol (CBD) has been explored as a potential treatment for migraine primarily based on its known anti-inflammatory, analgesic, and anti-emetic properties. However, the scientific evidence supporting its use for migraine is limited and largely preliminary. Most studies to date have focused on cannabis as a whole (containing both THC and CBD), rather than CBD alone. There is anecdotal evidence and a few small-scale studies or surveys suggesting that cannabinoids may reduce the frequency or severity of migraine attacks. For example, a 2017 study presented at the Congress of the European Academy of Neurology indicated that a combination of THC and CBD could reduce acute migraine pain by 40.4% in study participants, but the research was small and not placebo-controlled. Another 2020 review in Frontiers in Neurology noted that while cannabinoids may have a role in migraine management, rigorous clinical trials are lacking, and the mechanism is not fully understood.

To date, there are no large, high-quality randomized controlled trials specifically evaluating pure CBD for migraine prevention or treatment. Most migraine management guidelines do not recommend CBD due to insufficient evidence. Therefore, while there is some scientific rationale and preliminary investigation, the evidence is weak and insufficient for strong clinical endorsement at this time.

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