Evidence supporting the use of: Cannabinoids
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Cannabinoids, including compounds such as THC and CBD found in cannabis, have been explored for their potential in treating migraine. Scientific interest stems from the endocannabinoid system’s role in modulating pain, inflammation, and neurological signaling. Some observational studies and small clinical trials suggest that cannabinoids may reduce the frequency or severity of migraine attacks in some patients, particularly those who do not respond to conventional treatments. For example, a 2017 study presented at the Congress of the European Academy of Neurology reported that a combination of THC and CBD reduced acute migraine pain by 43.5% in some participants. Additionally, retrospective surveys have indicated that some individuals self-medicate with cannabis and perceive benefit. However, the overall quality of evidence is low, with most data coming from small, non-randomized, or open-label studies. There is a lack of large, placebo-controlled clinical trials, and concerns remain regarding dosing, long-term safety, dependency, and side effects. Official guidelines from major headache societies do not currently endorse cannabinoids as a first-line migraine therapy due to insufficient evidence. In conclusion, while there is some emerging scientific evidence suggesting a possible role for cannabinoids in migraine management, it is limited and not yet robust enough to fully justify widespread clinical use.

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