Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Coenzyme Q10 (CoQ10) is supported by scientific evidence for the prevention and treatment of migraine. Several clinical studies have investigated its effectiveness, focusing on its role in mitochondrial function and oxidative stress, factors thought to contribute to migraine pathophysiology. A notable randomized controlled trial published in Neurology (2005) demonstrated that daily supplementation with 100 mg of CoQ10 three times a day significantly reduced migraine attack frequency, headache days, and days with nausea compared to placebo. Other meta-analyses and systematic reviews have found that CoQ10 supplementation (typically 100-400 mg/day) is associated with a reduction in migraine frequency and severity, particularly among adult sufferers.

CoQ10 is believed to aid in migraine prevention by improving mitochondrial energy metabolism, as mitochondrial dysfunction has been implicated in migraine pathogenesis. It also exhibits antioxidant properties, which may help reduce neuroinflammation and oxidative stress linked to migraine attacks. The American Academy of Neurology and the American Headache Society recognize CoQ10 as "probably effective" for migraine prevention, especially in individuals seeking alternative or adjunctive therapies.

While CoQ10 is generally well-tolerated and considered safe, the magnitude of benefit is moderate, and not all patients respond. More large-scale, high-quality studies are needed to confirm optimal dosing and long-term efficacy. Nonetheless, current evidence supports the use of CoQ10 as a reasonable option for migraine prophylaxis, particularly for those who prefer non-pharmacological interventions.

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Other ingredients used for Migraine

Other health conditions supported by coenzyme Q10 (CoQ10)

Products containing coenzyme Q10 (CoQ10)

Pure Encapsulations Athletic Nutrients
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Pure Encapsulations Energize Plus™ Pure Pack
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Designs For Health Mito-NR™
Pure Encapsulations Mitochondria-ATP
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Pure Encapsulations NeuroMood Pure Pack
Metagenics NutraGems® CoQ10 300
Pure Encapsulations O.N.E.™ Multivitamin
Pure Encapsulations O.N.E.™ Multivitamin
Pure Encapsulations O.N.E.™ Multivitamin
Thorne Omega-3 w/ CoQ10
Thorne Ovarian Care
Integrative Therapeutics ProThrivers Wellness Flav Complex
Pure Encapsulations PureGenomics® UltraMultivitamin
Designs For Health Q-Evail® 100
Designs For Health Q-Evail® 200
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Pure Encapsulations Renual
Pure Encapsulations RevitalAge™ Nerve
Pure Encapsulations RevitalAge™ Ultra
Designs For Health RYR Synergy™
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Vitabase Super Fat Burner
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Pure Encapsulations Ubiquinol-QH 200 mg
Pure Encapsulations Ubiquinol VESIsorb®
Integrative Therapeutics UBQH 100 mg
Douglas Laboratories Ultra Preventive 50+ -EZ Swallow
Douglas Laboratories Ultra Preventive One Daily
Pure Encapsulations Ultra Pure Pack
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Pure Encapsulations UltraNutrient®
Pure Encapsulations UltraNutrient®
Pure Encapsulations UltraNutrient®
Metagenics Wellness Essentials Brain Health Daily Packs