Evidence supporting the use of: Corydalis
For the health condition: Migraine
Synopsis
Source of validity: Traditional
Rating (out of 5): 2
Corydalis (Corydalis yanhusuo) has a long history of use in Traditional Chinese Medicine (TCM) for managing pain-related conditions, including headaches and migraines. Its traditional application is often as part of herbal formulas designed to "invigorate the blood" and "move qi," which, according to TCM principles, can help alleviate various types of pain. Corydalis is thought to exert analgesic effects, and its primary active constituent, tetrahydropalmatine (THP), is known to interact with dopaminergic and other neurotransmitter systems, which could theoretically impact pain perception.
However, while preclinical studies and some small clinical studies suggest Corydalis and THP have analgesic properties, there is a lack of robust clinical evidence specifically supporting its efficacy in treating or preventing migraines. Most available studies are either animal-based or focus on general pain relief rather than migraine-specific outcomes. No large-scale, high-quality randomized controlled trials (RCTs) currently validate its use specifically for migraine.
In summary, while Corydalis is traditionally used for headache and pain in TCM, and there is some pharmacological rationale and preclinical evidence for its analgesic activity, direct scientific validation for its use in migraine is limited. Thus, its use for migraine is primarily justified by tradition, with modest supporting evidence.
Other ingredients used for Migraine
5-Hydroxytryptophan (5-HTP)alpha-linolenic acid (ALA)
ashwagandha
bergamot
beta caryophyllene
black tea
Indian frankincense
bupleurum falcatum
Chinese salvia root
coenzyme Q10 (CoQ10)
turmeric
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
feverfew
fish oil
ginger
ginkgo biloba
gooseberry
gotu kola
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
luteolin
magnesium
melatonin
moringa
niacin (vitamin B3)
omega-3 fatty acids
Peppermint
phytocannabinoids
pine bark
purple butterbur root
riboflavin (vitamin B2)
specialized pro-resolving mediators (SPMs)
Almond fruit
ubiquinol
valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
zinc
atractylodes
blackboard tree
swertia
Szechuan lovage
chrysanthemum
soursop
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
Apple Cider Vinegar
Albizia
Alpha-Lipoic Acid
Atractylone
Betony
Black Seed
Baikal Skullcap
Beta-hydroxybutyrate
Blepharis
Balsam
Banyan
Brahmi
Butterbur
Bifidobacteria
Black Hellebore
Chinese Silkvine
Crocin
Creatine
Cannabidiol
Corydalis
Carthamus
cola nut
Docosahexaenoic Acid
Danshen
Eicosapentaenoic Acid
Folic Acid
Flavin mononucleotide
Ficus religiosa
Fish
Flavanones
Ficus simplicissima
Frankincense
Goldthread
Gelsemium
Ginkgolides
Ginkgoside
Hellebore
iridoids
Ketone Salts
Kuding tea
lemon balm
Lesser speargrass
Little ironweed
Linalool
Mesua
Methylxanthine
Meadowsweet
Nardostachys
Night jessamine
Osthole
Puerarin
Petasines
Phthalides
Paeoniflorin
Pycnogenol
Polygonum
Palmitoylethanolamide (PEA)
Rue
Rubus
Rauvolfia
Rubiaceae
Spikenard
Sensitive Plant
Salmon Oil
Sandalwood
Scabrous Gentian
Uncaria
Withanolides
Xanthine
Xanthophyll
Xanthone
Yuzu
Zingerone