Evidence supporting the use of: Corydalis
For the health condition: Migraine
Synopsis
Source of validity: Traditional
Rating (out of 5): 2
Corydalis (Corydalis yanhusuo) has a long history of use in Traditional Chinese Medicine (TCM) for managing pain-related conditions, including headaches and migraines. Its traditional application is often as part of herbal formulas designed to "invigorate the blood" and "move qi," which, according to TCM principles, can help alleviate various types of pain. Corydalis is thought to exert analgesic effects, and its primary active constituent, tetrahydropalmatine (THP), is known to interact with dopaminergic and other neurotransmitter systems, which could theoretically impact pain perception.
However, while preclinical studies and some small clinical studies suggest Corydalis and THP have analgesic properties, there is a lack of robust clinical evidence specifically supporting its efficacy in treating or preventing migraines. Most available studies are either animal-based or focus on general pain relief rather than migraine-specific outcomes. No large-scale, high-quality randomized controlled trials (RCTs) currently validate its use specifically for migraine.
In summary, while Corydalis is traditionally used for headache and pain in TCM, and there is some pharmacological rationale and preclinical evidence for its analgesic activity, direct scientific validation for its use in migraine is limited. Thus, its use for migraine is primarily justified by tradition, with modest supporting evidence.
Other ingredients used for Migraine
1,3,7-Trimethylpurine-2,6-dione5-Hydroxytryptophan (5-HTP)
5-methyltetrahydrofolate glucosamine
Albizia
Almond fruit
alpha-linolenic acid (ALA)
alpha-lipoic acid
apple cider vinegar
ashwagandha
atractylodes
atractylone
Baikal Skullcap
balsam
banyan
bergamot
beta caryophyllene
beta-hydroxybutyrate
betony
Bifidobacteria
Black Hellebore
black seed
black tea
blackboard tree
Blepharis
brahmi
bupleurum falcatum
butterbur
cannabidiol
Carthamus
Chinese salvia root
Chinese silkvine
chrysanthemum
coenzyme Q10 (CoQ10)
cola nut
Corydalis
creatine
crocin
curcumin
danshen
DHA (docosahexaenoic acid)
docosahexaenoic Acid
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
feverfew
Ficus religiosa
Ficus simplicissima
fish
fish oil
flavanones
flavin mononucleotide
folic acid
frankincense
Gelsemium
ginger
ginkgo biloba
ginkgolides
Ginkgoside
goldthread
gooseberry
gotu kola
Hellebore
Indian frankincense
iridoids
ketone salts
kuding tea
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
lemon balm
Lesser speargrass
linalool
little ironweed
luteolin
magnesium
Meadowsweet
Melatonin
Mesua
Methylxanthine
Moringa
Nardostachys
Niacin (vitamin B3)
Night jessamine
omega-3 fatty acids
Osthole
paeoniflorin
Palmitoylethanolamide (PEA)
Peppermint
Petasines
Phthalides
phytocannabinoids
pine bark
Polygonum
Puerarin
purple butterbur root
Pycnogenol
Rauvolfia
riboflavin (vitamin B2)
Rubiaceae
Rubus
rue
Salmon Oil
Sandalwood
Scabrous Gentian
Sensitive Plant
soursop
specialized pro-resolving mediators (SPMs)
Spikenard
Swertia
Szechuan lovage
turmeric
ubiquinol
Uncaria
Valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
Withanolides
Xanthine
Xanthone
Xanthophyll
Yuzu
Zinc
Zingerone