Evidence supporting the use of: Creatine
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Creatine is being investigated as a potential adjunct in the management of migraines, with some preliminary scientific evidence supporting its use. The rationale is based on creatine's role in cellular energy metabolism. Migraine pathophysiology is thought, in part, to involve mitochondrial dysfunction and impaired energy metabolism in the brain. Creatine, as a substrate for the regeneration of ATP, may help support energy-demanding neuronal processes and reduce the susceptibility to migraine attacks.

A small number of clinical studies and case reports have examined creatine supplementation in migraine patients. For example, a pilot study published in Cephalalgia (2012) found that creatine supplementation improved brain energy metabolism (measured by MR spectroscopy) in adolescent migraineurs, although changes in migraine frequency were not significant. Other studies in related disorders, such as mitochondrial diseases with migraine-like symptoms, have shown that creatine may reduce headache frequency.

However, high-quality randomized controlled trials in migraine patients are lacking, and the existing evidence is limited and preliminary. Therefore, while the use of creatine for migraines is scientifically plausible and supported by early-stage research, it cannot yet be considered an established or broadly endorsed treatment. More rigorous clinical trials are needed to determine its efficacy and safety for this indication.

More about creatine
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Other ingredients used for Migraine

1,3,7-Trimethylpurine-2,6-dione
5-Hydroxytryptophan (5-HTP)
5-methyltetrahydrofolate glucosamine
Albizia
Almond fruit
alpha-linolenic acid (ALA)
alpha-lipoic acid
apple cider vinegar
ashwagandha
atractylodes
atractylone
Baikal Skullcap
balsam
banyan
bergamot
beta caryophyllene
beta-hydroxybutyrate
betony
Bifidobacteria
Black Hellebore
black seed
black tea
blackboard tree
Blepharis
brahmi
bupleurum falcatum
butterbur
cannabidiol
Carthamus
Chinese salvia root
Chinese silkvine
chrysanthemum
coenzyme Q10 (CoQ10)
cola nut
Corydalis
creatine
crocin
curcumin
danshen
DHA (docosahexaenoic acid)
docosahexaenoic Acid
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
feverfew
Ficus religiosa
Ficus simplicissima
fish
fish oil
flavanones
flavin mononucleotide
folic acid
frankincense
Gelsemium
ginger
ginkgo biloba
ginkgolides
Ginkgoside
goldthread
gooseberry
gotu kola
Hellebore
Indian frankincense
iridoids
ketone salts
kuding tea
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
lemon balm
Lesser speargrass
linalool
little ironweed
luteolin
magnesium
Meadowsweet
Melatonin
Mesua
Methylxanthine
Moringa
Nardostachys
Niacin (vitamin B3)
Night jessamine
omega-3 fatty acids
Osthole
paeoniflorin
Palmitoylethanolamide (PEA)
Peppermint
Petasines
Phthalides
phytocannabinoids
pine bark
Polygonum
Puerarin
purple butterbur root
Pycnogenol
Rauvolfia
riboflavin (vitamin B2)
Rubiaceae
Rubus
rue
Salmon Oil
Sandalwood
Scabrous Gentian
Sensitive Plant
soursop
specialized pro-resolving mediators (SPMs)
Spikenard
Swertia
Szechuan lovage
turmeric
ubiquinol
Uncaria
Valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
Withanolides
Xanthine
Xanthone
Xanthophyll
Yuzu
Zinc
Zingerone

Products containing creatine

We currently have no products on Vitabase that contain this ingredient.