Evidence supporting the use of: Creatine
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Creatine is being investigated as a potential adjunct in the management of migraines, with some preliminary scientific evidence supporting its use. The rationale is based on creatine's role in cellular energy metabolism. Migraine pathophysiology is thought, in part, to involve mitochondrial dysfunction and impaired energy metabolism in the brain. Creatine, as a substrate for the regeneration of ATP, may help support energy-demanding neuronal processes and reduce the susceptibility to migraine attacks.

A small number of clinical studies and case reports have examined creatine supplementation in migraine patients. For example, a pilot study published in Cephalalgia (2012) found that creatine supplementation improved brain energy metabolism (measured by MR spectroscopy) in adolescent migraineurs, although changes in migraine frequency were not significant. Other studies in related disorders, such as mitochondrial diseases with migraine-like symptoms, have shown that creatine may reduce headache frequency.

However, high-quality randomized controlled trials in migraine patients are lacking, and the existing evidence is limited and preliminary. Therefore, while the use of creatine for migraines is scientifically plausible and supported by early-stage research, it cannot yet be considered an established or broadly endorsed treatment. More rigorous clinical trials are needed to determine its efficacy and safety for this indication.

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