Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Crocin is a major bioactive compound found in saffron (Crocus sativus). Several preclinical and clinical studies have investigated its role in the management of migraine. Crocin possesses antioxidant, anti-inflammatory, and neuroprotective properties, which are hypothesized to be beneficial in migraine, a disorder associated with neurogenic inflammation and oxidative stress.

Recent randomized controlled trials (RCTs) have provided scientific evidence supporting crocin’s efficacy in migraine management. For example, a double-blind, placebo-controlled clinical trial published in 2019 demonstrated that crocin supplementation (30 mg/day) for eight weeks significantly reduced the frequency, duration, and severity of migraine attacks compared to placebo. The proposed mechanisms include reduction of oxidative stress markers and modulation of inflammatory cytokines, both implicated in migraine pathophysiology. Other studies suggest crocin may influence neurotransmitter balance, particularly serotonin pathways, which play a role in migraine attacks.

While these results are promising, most studies to date have had relatively small sample sizes and short durations. Nevertheless, the consistency of findings across several RCTs provides moderate to strong scientific support for crocin’s use in migraine. Larger, multi-center trials are warranted to further establish efficacy and safety. Overall, crocin is scientifically supported as a potential adjunct treatment for migraine, particularly for patients seeking alternatives to conventional pharmacotherapy.

More about Crocin
More about Migraine

Other ingredients used for Migraine

5-Hydroxytryptophan (5-HTP)
alpha-linolenic acid (ALA)
ashwagandha
bergamot
beta caryophyllene
black tea
Indian frankincense
bupleurum falcatum
Chinese salvia root
coenzyme Q10 (CoQ10)
turmeric
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
feverfew
fish oil
ginger
ginkgo biloba
gooseberry
gotu kola
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
luteolin
magnesium
melatonin
moringa
niacin (vitamin B3)
omega-3 fatty acids
Peppermint
phytocannabinoids
pine bark
purple butterbur root
riboflavin (vitamin B2)
specialized pro-resolving mediators (SPMs)
Almond fruit
ubiquinol
valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
zinc
atractylodes
blackboard tree
swertia
Szechuan lovage
chrysanthemum
soursop
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
Apple Cider Vinegar
Albizia
Alpha-Lipoic Acid
Atractylone
Betony
Black Seed
Baikal Skullcap
Beta-hydroxybutyrate
Blepharis
Balsam
Banyan
Brahmi
Butterbur
Bifidobacteria
Black Hellebore
Chinese Silkvine
Crocin
Creatine
Cannabidiol
Corydalis
Carthamus
cola nut
Docosahexaenoic Acid
Danshen
Eicosapentaenoic Acid
Folic Acid
Flavin mononucleotide
Ficus religiosa
Fish
Flavanones
Ficus simplicissima
Frankincense
Goldthread
Gelsemium
Ginkgolides
Ginkgoside
Hellebore
iridoids
Ketone Salts
Kuding tea
lemon balm
Lesser speargrass
Little ironweed
Linalool
Mesua
Methylxanthine
Meadowsweet
Nardostachys
Night jessamine
Osthole
Puerarin
Petasines
Phthalides
Paeoniflorin
Pycnogenol
Polygonum
Palmitoylethanolamide (PEA)
Rue
Rubus
Rauvolfia
Rubiaceae
Spikenard
Sensitive Plant
Salmon Oil
Sandalwood
Scabrous Gentian
Uncaria
Withanolides
Xanthine
Xanthophyll
Xanthone
Yuzu
Zingerone

Other health conditions supported by Crocin

Alzheimer's Disease
Depression
Diabetes
Inflammation
Migraine

Products containing Crocin

We currently have no products on Vitabase that contain this ingredient.