Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Crocin is a major bioactive compound found in saffron (Crocus sativus). Several preclinical and clinical studies have investigated its role in the management of migraine. Crocin possesses antioxidant, anti-inflammatory, and neuroprotective properties, which are hypothesized to be beneficial in migraine, a disorder associated with neurogenic inflammation and oxidative stress.

Recent randomized controlled trials (RCTs) have provided scientific evidence supporting crocin’s efficacy in migraine management. For example, a double-blind, placebo-controlled clinical trial published in 2019 demonstrated that crocin supplementation (30 mg/day) for eight weeks significantly reduced the frequency, duration, and severity of migraine attacks compared to placebo. The proposed mechanisms include reduction of oxidative stress markers and modulation of inflammatory cytokines, both implicated in migraine pathophysiology. Other studies suggest crocin may influence neurotransmitter balance, particularly serotonin pathways, which play a role in migraine attacks.

While these results are promising, most studies to date have had relatively small sample sizes and short durations. Nevertheless, the consistency of findings across several RCTs provides moderate to strong scientific support for crocin’s use in migraine. Larger, multi-center trials are warranted to further establish efficacy and safety. Overall, crocin is scientifically supported as a potential adjunct treatment for migraine, particularly for patients seeking alternatives to conventional pharmacotherapy.

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Other ingredients used for Migraine

1,3,7-Trimethylpurine-2,6-dione
5-Hydroxytryptophan (5-HTP)
5-methyltetrahydrofolate glucosamine
Albizia
Almond fruit
alpha-linolenic acid (ALA)
alpha-lipoic acid
apple cider vinegar
ashwagandha
atractylodes
atractylone
Baikal Skullcap
balsam
banyan
bergamot
beta caryophyllene
beta-hydroxybutyrate
betony
Bifidobacteria
Black Hellebore
black seed
black tea
blackboard tree
Blepharis
brahmi
bupleurum falcatum
butterbur
cannabidiol
Carthamus
Chinese salvia root
Chinese silkvine
chrysanthemum
coenzyme Q10 (CoQ10)
cola nut
Corydalis
creatine
crocin
curcumin
danshen
DHA (docosahexaenoic acid)
docosahexaenoic Acid
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
feverfew
Ficus religiosa
Ficus simplicissima
fish
fish oil
flavanones
flavin mononucleotide
folic acid
frankincense
Gelsemium
ginger
ginkgo biloba
ginkgolides
Ginkgoside
goldthread
gooseberry
gotu kola
Hellebore
Indian frankincense
iridoids
ketone salts
kuding tea
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
lemon balm
Lesser speargrass
linalool
little ironweed
luteolin
magnesium
Meadowsweet
Melatonin
Mesua
Methylxanthine
Moringa
Nardostachys
Niacin (vitamin B3)
Night jessamine
omega-3 fatty acids
Osthole
paeoniflorin
Palmitoylethanolamide (PEA)
Peppermint
Petasines
Phthalides
phytocannabinoids
pine bark
Polygonum
Puerarin
purple butterbur root
Pycnogenol
Rauvolfia
riboflavin (vitamin B2)
Rubiaceae
Rubus
rue
Salmon Oil
Sandalwood
Scabrous Gentian
Sensitive Plant
soursop
specialized pro-resolving mediators (SPMs)
Spikenard
Swertia
Szechuan lovage
turmeric
ubiquinol
Uncaria
Valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
Withanolides
Xanthine
Xanthone
Xanthophyll
Yuzu
Zinc
Zingerone

Other health conditions supported by crocin

Alzheimer's Disease
Depression
Diabetes
Inflammation
Migraine

Products containing crocin

We currently have no products on Vitabase that contain this ingredient.