Evidence supporting the use of: Crocin
For the health condition: Migraine

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Crocin is a major bioactive compound found in saffron (Crocus sativus). Several preclinical and clinical studies have investigated its role in the management of migraine. Crocin possesses antioxidant, anti-inflammatory, and neuroprotective properties, which are hypothesized to be beneficial in migraine, a disorder associated with neurogenic inflammation and oxidative stress.

Recent randomized controlled trials (RCTs) have provided scientific evidence supporting crocin’s efficacy in migraine management. For example, a double-blind, placebo-controlled clinical trial published in 2019 demonstrated that crocin supplementation (30 mg/day) for eight weeks significantly reduced the frequency, duration, and severity of migraine attacks compared to placebo. The proposed mechanisms include reduction of oxidative stress markers and modulation of inflammatory cytokines, both implicated in migraine pathophysiology. Other studies suggest crocin may influence neurotransmitter balance, particularly serotonin pathways, which play a role in migraine attacks.

While these results are promising, most studies to date have had relatively small sample sizes and short durations. Nevertheless, the consistency of findings across several RCTs provides moderate to strong scientific support for crocin’s use in migraine. Larger, multi-center trials are warranted to further establish efficacy and safety. Overall, crocin is scientifically supported as a potential adjunct treatment for migraine, particularly for patients seeking alternatives to conventional pharmacotherapy.

More about Crocin
More about Migraine

Other health conditions supported by Crocin

Alzheimer's Disease
Depression
Diabetes
Inflammation
Migraine

Products containing Crocin

We currently have no products on Vitabase that contain this ingredient.