Evidence supporting the use of: Curcumin
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Curcumin, the primary bioactive compound in turmeric (Curcuma longa), has been investigated for its potential role in supporting or treating migraine, primarily due to its anti-inflammatory and antioxidant properties. Scientific interest has grown as inflammation and oxidative stress are increasingly recognized as key components in migraine pathophysiology. Several preclinical studies have shown that curcumin can modulate inflammatory cytokines and oxidative markers relevant to migraine. A handful of small clinical trials and pilot studies have investigated curcumin supplementation in migraine patients. For instance, a randomized controlled trial published in 2020 found that curcumin, particularly when combined with coenzyme Q10, reduced the frequency and severity of migraine attacks compared to placebo. Another study indicated improvements in migraine-related biomarkers after curcumin supplementation. However, these studies often have limitations such as small sample sizes, short durations, and variability in formulations and dosages used.

While curcumin is not a traditional remedy specifically for migraine in historical or folk medicine, its general use for pain and inflammation in traditional Indian and Chinese medicine provides some indirect support for its consideration. Nevertheless, the scientific evidence for curcumin’s efficacy in migraine remains preliminary. Larger, high-quality clinical trials are necessary to confirm its benefits and to determine optimal dosing and safety for long-term use in migraine sufferers. Thus, while there is emerging scientific interest and some early positive data, the current level of evidence is modest.

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Other ingredients used for Migraine

1,3,7-Trimethylpurine-2,6-dione
5-Hydroxytryptophan (5-HTP)
5-methyltetrahydrofolate glucosamine
Albizia
Almond fruit
alpha-linolenic acid (ALA)
alpha-lipoic acid
apple cider vinegar
ashwagandha
atractylodes
atractylone
Baikal Skullcap
balsam
banyan
bergamot
beta caryophyllene
beta-hydroxybutyrate
betony
Bifidobacteria
Black Hellebore
black seed
black tea
blackboard tree
Blepharis
brahmi
bupleurum falcatum
butterbur
cannabidiol
Carthamus
Chinese salvia root
Chinese silkvine
chrysanthemum
coenzyme Q10 (CoQ10)
cola nut
Corydalis
creatine
crocin
curcumin
danshen
DHA (docosahexaenoic acid)
docosahexaenoic Acid
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
feverfew
Ficus religiosa
Ficus simplicissima
fish
fish oil
flavanones
flavin mononucleotide
folic acid
frankincense
Gelsemium
ginger
ginkgo biloba
ginkgolides
Ginkgoside
goldthread
gooseberry
gotu kola
Hellebore
Indian frankincense
iridoids
ketone salts
kuding tea
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
lemon balm
Lesser speargrass
linalool
little ironweed
luteolin
magnesium
Meadowsweet
Melatonin
Mesua
Methylxanthine
Moringa
Nardostachys
Niacin (vitamin B3)
Night jessamine
omega-3 fatty acids
Osthole
paeoniflorin
Palmitoylethanolamide (PEA)
Peppermint
Petasines
Phthalides
phytocannabinoids
pine bark
Polygonum
Puerarin
purple butterbur root
Pycnogenol
Rauvolfia
riboflavin (vitamin B2)
Rubiaceae
Rubus
rue
Salmon Oil
Sandalwood
Scabrous Gentian
Sensitive Plant
soursop
specialized pro-resolving mediators (SPMs)
Spikenard
Swertia
Szechuan lovage
turmeric
ubiquinol
Uncaria
Valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
Withanolides
Xanthine
Xanthone
Xanthophyll
Yuzu
Zinc
Zingerone