Evidence supporting the use of: Curcumin
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Curcumin, the primary bioactive compound in turmeric (Curcuma longa), has been investigated for its potential role in supporting or treating migraine, primarily due to its anti-inflammatory and antioxidant properties. Scientific interest has grown as inflammation and oxidative stress are increasingly recognized as key components in migraine pathophysiology. Several preclinical studies have shown that curcumin can modulate inflammatory cytokines and oxidative markers relevant to migraine. A handful of small clinical trials and pilot studies have investigated curcumin supplementation in migraine patients. For instance, a randomized controlled trial published in 2020 found that curcumin, particularly when combined with coenzyme Q10, reduced the frequency and severity of migraine attacks compared to placebo. Another study indicated improvements in migraine-related biomarkers after curcumin supplementation. However, these studies often have limitations such as small sample sizes, short durations, and variability in formulations and dosages used.

While curcumin is not a traditional remedy specifically for migraine in historical or folk medicine, its general use for pain and inflammation in traditional Indian and Chinese medicine provides some indirect support for its consideration. Nevertheless, the scientific evidence for curcumin’s efficacy in migraine remains preliminary. Larger, high-quality clinical trials are necessary to confirm its benefits and to determine optimal dosing and safety for long-term use in migraine sufferers. Thus, while there is emerging scientific interest and some early positive data, the current level of evidence is modest.

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