Relationship: Migraine and DHA (docosahexaeonic acid)

Evidence supporting the use of: DHA (docosahexaeonic acid)
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

DHA (docosahexaenoic acid), an omega-3 fatty acid found abundantly in fish oil, has been investigated for its potential role in migraine prevention and management. The scientific rationale is based on DHA's anti-inflammatory properties and its role in maintaining neuronal membrane fluidity and function. Migraines are thought to involve neurogenic inflammation and changes in neuronal excitability, so omega-3s like DHA could plausibly help by reducing neuroinflammation and modulating neurotransmission.

Several small clinical studies and observational reports have suggested that omega-3 supplementation (including DHA and EPA) can reduce migraine frequency, duration, or severity in some people. For example, randomized controlled trials (RCTs) have shown modest reductions in headache days among migraine sufferers supplementing with fish oil containing DHA. However, these studies often use combination omega-3 products (not DHA alone), have limited sample sizes, and sometimes show mixed results. Systematic reviews conclude that evidence is promising but insufficient for strong recommendations, and that further large, high-quality RCTs are needed.

While there is no widespread traditional use of DHA specifically for migraine, the existing scientific evidence, though limited and mixed, provides some justification for its use as an adjunctive therapy. The current strength of evidence is rated 2 out of 5, reflecting preliminary support but a lack of definitive clinical endorsement.

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Other ingredients used for Migraine

5-Hydroxytryptophan (5-HTP)
alpha-linolenic acid (ALA)
ashwagandha
bergamot
beta caryophyllene
black tea
Indian frankincense
bupleurum falcatum
Chinese salvia root
coenzyme Q10 (CoQ10)
turmeric
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
feverfew
fish oil
ginger
ginkgo biloba
gooseberry
gotu kola
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
luteolin
magnesium
melatonin
moringa
niacin (vitamin B3)
omega-3 fatty acids
peppermint oil
phytocannabinoids
pine bark
purple butterbur root
riboflavin (vitamin B2)
specialized pro-resolving mediators (SPMs)
almond fruit
ubiquinol
valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
zinc
atractylodes
blackboard tree
swertia
lingusticum wallichii
chrysanthemum
soursop
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
Apple Cider Vinegar
Albizia
Alpha-Lipoic Acid
Acetylsalicylic acid
Atractylone
Betony
Black Seed
Baikal Skullcap
Beta-hydroxybutyrate
Blepharis
Balsam
Banyan
Brahmi
Butterbur
Bifidobacteria
Black Hellebore
Chinese Silkvine
Crocin
Creatine
Cannabidiol
Corydalis
Carthamus
cola nut
Docosahexaenoic Acid
Danshen
Eicosapentaenoic Acid
Folic Acid
Goldthread
Ketone Salts
Little ironweed
Spikenard
Sandalwood

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Evidence supporting the use of: DHA (docosahexaeonic acid)
For the health condition: Migraine

Table of Contents

Synopsis

Other ingredients used for Migraine

Other health conditions supported by DHA (docosahexaeonic acid)

Products containing DHA (docosahexaeonic acid)

Health Concerns

Brands

Evidence supporting the use of: DHA (docosahexaeonic acid)For the health condition: Migraine

Table of Contents

Synopsis

Other ingredients used for Migraine

Other health conditions supported by DHA (docosahexaeonic acid)

Products containing DHA (docosahexaeonic acid)

Evidence supporting the use of: DHA (docosahexaeonic acid)
For the health condition: Migraine