Synopsis

Source of validity: Scientific
Rating (out of 5): 2

DHA (docosahexaenoic acid), an omega-3 fatty acid found abundantly in fish oil, has been investigated for its potential role in migraine prevention and management. The scientific rationale is based on DHA's anti-inflammatory properties and its role in maintaining neuronal membrane fluidity and function. Migraines are thought to involve neurogenic inflammation and changes in neuronal excitability, so omega-3s like DHA could plausibly help by reducing neuroinflammation and modulating neurotransmission.

Several small clinical studies and observational reports have suggested that omega-3 supplementation (including DHA and EPA) can reduce migraine frequency, duration, or severity in some people. For example, randomized controlled trials (RCTs) have shown modest reductions in headache days among migraine sufferers supplementing with fish oil containing DHA. However, these studies often use combination omega-3 products (not DHA alone), have limited sample sizes, and sometimes show mixed results. Systematic reviews conclude that evidence is promising but insufficient for strong recommendations, and that further large, high-quality RCTs are needed.

While there is no widespread traditional use of DHA specifically for migraine, the existing scientific evidence, though limited and mixed, provides some justification for its use as an adjunctive therapy. The current strength of evidence is rated 2 out of 5, reflecting preliminary support but a lack of definitive clinical endorsement.

More about DHA (docosahexaenoic acid)
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Products containing DHA (docosahexaenoic acid)

Thorne Advanced DHA
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Pure Encapsulations DHA Ultimate
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Pure Encapsulations EPA Ultimate
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Metagenics MetaKids DHA
Metagenics MetaKids Nutrition Powder Chocolate
Metagenics MetaKids Nutrition Powder Vanilla
Pure Encapsulations NeuroMood Pure Pack
Pure Encapsulations O.N.E.™ Omega
Pure Encapsulations O.N.E.™ Omega
Thorne Omega-3 w/ CoQ10
Thorne Omega Superb Lemon Berry
Metagenics OmegaGenics Algae EPA-DHA 300 mg
Metagenics OmegaGenics EPA DHA 2400 Fish Oil
Metagenics OmegaGenics EPA-DHA 300 Lemon Lime
Metagenics OmegaGenics Fish Oil EPA-DHA 1000 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 1000 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 500 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 500 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 720 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 720 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 720 mg
Metagenics OmegaGenics Fish Oil Mega 10®
Metagenics OmegaGenics Neuro 1000 mg
Designs For Health OmegAvail™ Hi-Po
Designs For Health OmegAvail™ Hi-Po
Designs For Health OmegAvail™ Hi-Po Liquid
Designs For Health OmegAvail™ Liquid
Designs For Health OmegAvail™ Synergy
Designs For Health OmegAvail™ Synergy
Designs For Health OmegAvail™ TG1000
Designs For Health OmegAvail™ Ultra
Designs For Health OmegAvail™ Ultra
Designs For Health OmegAvail™ Ultra DHA
Designs For Health OmegAvail™ Ultra with Vitamin D3, K1 and K2
Douglas Laboratories Opti-EPA 500 ™ Cholesterol Free
Douglas Laboratories Opti-EPA 500 ™ Cholesterol Free
Metagenics PlusOne® Daily Prenatal Packs
Thorne Prenatal DHA
Pure Encapsulations Pro-Resolve Omega
Thorne Pro-Resolving Mediators
Integrative Therapeutics Pure Omega HP
Integrative Therapeutics Pure Omega Liquid
Integrative Therapeutics Pure Omega Ultra HP
Pure Encapsulations PureNutrients EPA/DHA
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Douglas Laboratories QUELL Fish Oil ® - EPA/DHA Plus D
Metagenics SPM Active
Thorne Super EPA
Thorne Super EPA NSF
Thorne Super EPA Pro
Vitabase Super Omega-3
Douglas Laboratories Ultra G.L.A. Borage Oil
Douglas Laboratories Ultra G.L.A. Borage Oil
Pure Encapsulations Ultra Pure Pack
Pure Encapsulations VisionPro EPA/DHA/GLA
Pure Encapsulations VisionPro EPA/DHA/GLA
Metagenics Wellness Essentials Active Daily Packs
Metagenics Wellness Essentials Brain Health Daily Packs
Metagenics Wellness Essentials® Daily Packs
Metagenics Wellness Essentials Healthy Balance Daily Packs
Metagenics Wellness Essentials Men's Vitality Daily Packs
Metagenics Wellness Essentials Women's Daily Packs
Metagenics Wellness Essentials Women's Prime Daily Packs
Designs For Health XanthOmega™ Krill Oil