Evidence supporting the use of: Flavin mononucleotide
For the health condition: Migraine
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Flavin mononucleotide (FMN), also known as riboflavin-5'-phosphate, is closely related to riboflavin (vitamin B2). In the context of migraine prevention, it is riboflavin that has been studied in clinical trials, not FMN specifically. Riboflavin supplementation at high doses (typically 400 mg/day) has demonstrated efficacy in reducing migraine frequency and severity, especially in adults. The proposed mechanism involves improving mitochondrial energy metabolism, as some migraineurs may have mitochondrial dysfunction. FMN is a biologically active derivative of riboflavin and serves as a coenzyme in various oxidation-reduction reactions in the body. While FMN itself is not commonly used in clinical studies for migraine, it is sometimes included in supplements marketed for migraine support based on its relationship to riboflavin. Scientific evidence supporting riboflavin for migraine prevention is moderate. Several randomized controlled trials and meta-analyses, such as those published in Neurology (1998) and Headache (2017), indicate a benefit, particularly in adult populations. The American Academy of Neurology and the American Headache Society consider riboflavin “probably effective” for migraine prevention. However, the direct evidence for FMN is lacking, and its use is justified by extrapolation from riboflavin studies rather than direct clinical validation.
Other ingredients used for Migraine
5-Hydroxytryptophan (5-HTP)alpha-linolenic acid (ALA)
ashwagandha
bergamot
beta caryophyllene
black tea
Indian frankincense
bupleurum falcatum
Chinese salvia root
coenzyme Q10 (CoQ10)
turmeric
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
feverfew
fish oil
ginger
ginkgo biloba
gooseberry
gotu kola
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
luteolin
magnesium
melatonin
moringa
niacin (vitamin B3)
omega-3 fatty acids
Peppermint
phytocannabinoids
pine bark
purple butterbur root
riboflavin (vitamin B2)
specialized pro-resolving mediators (SPMs)
Almond fruit
ubiquinol
valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
zinc
atractylodes
blackboard tree
swertia
Szechuan lovage
chrysanthemum
soursop
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
Apple Cider Vinegar
Albizia
Alpha-Lipoic Acid
Atractylone
Betony
Black Seed
Baikal Skullcap
Beta-hydroxybutyrate
Blepharis
Balsam
Banyan
Brahmi
Butterbur
Bifidobacteria
Black Hellebore
Chinese Silkvine
Crocin
Creatine
Cannabidiol
Corydalis
Carthamus
cola nut
Docosahexaenoic Acid
Danshen
Eicosapentaenoic Acid
Folic Acid
Flavin mononucleotide
Ficus religiosa
Fish
Flavanones
Ficus simplicissima
Frankincense
Goldthread
Gelsemium
Ginkgolides
Ginkgoside
Hellebore
iridoids
Ketone Salts
Kuding tea
lemon balm
Lesser speargrass
Little ironweed
Linalool
Mesua
Methylxanthine
Meadowsweet
Nardostachys
Night jessamine
Osthole
Puerarin
Petasines
Phthalides
Paeoniflorin
Pycnogenol
Polygonum
Palmitoylethanolamide (PEA)
Rue
Rubus
Rauvolfia
Rubiaceae
Spikenard
Sensitive Plant
Salmon Oil
Sandalwood
Scabrous Gentian
Uncaria
Withanolides
Xanthine
Xanthophyll
Xanthone
Yuzu
Zingerone