Evidence supporting the use of: Flavin mononucleotide
For the health condition: Migraine
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Flavin mononucleotide (FMN), also known as riboflavin-5'-phosphate, is closely related to riboflavin (vitamin B2). In the context of migraine prevention, it is riboflavin that has been studied in clinical trials, not FMN specifically. Riboflavin supplementation at high doses (typically 400 mg/day) has demonstrated efficacy in reducing migraine frequency and severity, especially in adults. The proposed mechanism involves improving mitochondrial energy metabolism, as some migraineurs may have mitochondrial dysfunction. FMN is a biologically active derivative of riboflavin and serves as a coenzyme in various oxidation-reduction reactions in the body. While FMN itself is not commonly used in clinical studies for migraine, it is sometimes included in supplements marketed for migraine support based on its relationship to riboflavin. Scientific evidence supporting riboflavin for migraine prevention is moderate. Several randomized controlled trials and meta-analyses, such as those published in Neurology (1998) and Headache (2017), indicate a benefit, particularly in adult populations. The American Academy of Neurology and the American Headache Society consider riboflavin “probably effective” for migraine prevention. However, the direct evidence for FMN is lacking, and its use is justified by extrapolation from riboflavin studies rather than direct clinical validation.
Other ingredients used for Migraine
1,3,7-Trimethylpurine-2,6-dione5-Hydroxytryptophan (5-HTP)
5-methyltetrahydrofolate glucosamine
Albizia
Almond fruit
alpha-linolenic acid (ALA)
alpha-lipoic acid
apple cider vinegar
ashwagandha
atractylodes
atractylone
Baikal Skullcap
balsam
banyan
bergamot
beta caryophyllene
beta-hydroxybutyrate
betony
Bifidobacteria
Black Hellebore
black seed
black tea
blackboard tree
Blepharis
brahmi
bupleurum falcatum
butterbur
cannabidiol
Carthamus
Chinese salvia root
Chinese silkvine
chrysanthemum
coenzyme Q10 (CoQ10)
cola nut
Corydalis
creatine
crocin
curcumin
danshen
DHA (docosahexaenoic acid)
docosahexaenoic Acid
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
feverfew
Ficus religiosa
Ficus simplicissima
fish
fish oil
flavanones
flavin mononucleotide
folic acid
frankincense
Gelsemium
ginger
ginkgo biloba
ginkgolides
Ginkgoside
goldthread
gooseberry
gotu kola
Hellebore
Indian frankincense
iridoids
ketone salts
kuding tea
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
lemon balm
Lesser speargrass
linalool
little ironweed
luteolin
magnesium
Meadowsweet
Melatonin
Mesua
Methylxanthine
Moringa
Nardostachys
Niacin (vitamin B3)
Night jessamine
omega-3 fatty acids
Osthole
paeoniflorin
Palmitoylethanolamide (PEA)
Peppermint
Petasines
Phthalides
phytocannabinoids
pine bark
Polygonum
Puerarin
purple butterbur root
Pycnogenol
Rauvolfia
riboflavin (vitamin B2)
Rubiaceae
Rubus
rue
Salmon Oil
Sandalwood
Scabrous Gentian
Sensitive Plant
soursop
specialized pro-resolving mediators (SPMs)
Spikenard
Swertia
Szechuan lovage
turmeric
ubiquinol
Uncaria
Valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
Withanolides
Xanthine
Xanthone
Xanthophyll
Yuzu
Zinc
Zingerone