Evidence supporting the use of: Iridoids
For the health condition: Migraine

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Iridoids are a class of secondary metabolites commonly found in several medicinal plants, such as feverfew (Tanacetum parthenium) and valerian (Valeriana officinalis). Their use in supporting or treating migraine is primarily rooted in traditional and folk medicine. For example, feverfew, which contains parthenolide (an iridoid derivative), has been traditionally used in Europe for centuries to prevent migraines and alleviate related symptoms. Some early clinical studies in the late 20th century suggested a potential benefit of feverfew in reducing migraine frequency, but these studies were often small and methodologically limited. More recent systematic reviews and meta-analyses have concluded that the evidence is inconsistent and not robust enough to conclusively support efficacy.

While iridoids have demonstrated anti-inflammatory and neuroprotective effects in preclinical studies, direct evidence linking iridoids themselves (as opposed to whole plant extracts) to migraine prevention or treatment in humans is sparse. Thus, the use of iridoid-containing plants for migraine is mostly justified by tradition rather than strong scientific validation.

In summary, iridoids are used for migraine support mainly due to longstanding traditional practices, with scientific evidence rated as weak or inconclusive (2/5).

More about iridoids
More about Migraine

Other ingredients used for Migraine

1,3,7-Trimethylpurine-2,6-dione
5-Hydroxytryptophan (5-HTP)
5-methyltetrahydrofolate glucosamine
Albizia
Almond fruit
alpha-linolenic acid (ALA)
alpha-lipoic acid
apple cider vinegar
ashwagandha
atractylodes
atractylone
Baikal Skullcap
balsam
banyan
bergamot
beta caryophyllene
beta-hydroxybutyrate
betony
Bifidobacteria
Black Hellebore
black seed
black tea
blackboard tree
Blepharis
brahmi
bupleurum falcatum
butterbur
cannabidiol
Carthamus
Chinese salvia root
Chinese silkvine
chrysanthemum
coenzyme Q10 (CoQ10)
cola nut
Corydalis
creatine
crocin
curcumin
danshen
DHA (docosahexaenoic acid)
docosahexaenoic Acid
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
feverfew
Ficus religiosa
Ficus simplicissima
fish
fish oil
flavanones
flavin mononucleotide
folic acid
frankincense
Gelsemium
ginger
ginkgo biloba
ginkgolides
Ginkgoside
goldthread
gooseberry
gotu kola
Hellebore
Indian frankincense
iridoids
ketone salts
kuding tea
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
lemon balm
Lesser speargrass
linalool
little ironweed
luteolin
magnesium
Meadowsweet
Melatonin
Mesua
Methylxanthine
Moringa
Nardostachys
Niacin (vitamin B3)
Night jessamine
omega-3 fatty acids
Osthole
paeoniflorin
Palmitoylethanolamide (PEA)
Peppermint
Petasines
Phthalides
phytocannabinoids
pine bark
Polygonum
Puerarin
purple butterbur root
Pycnogenol
Rauvolfia
riboflavin (vitamin B2)
Rubiaceae
Rubus
rue
Salmon Oil
Sandalwood
Scabrous Gentian
Sensitive Plant
soursop
specialized pro-resolving mediators (SPMs)
Spikenard
Swertia
Szechuan lovage
turmeric
ubiquinol
Uncaria
Valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
Withanolides
Xanthine
Xanthone
Xanthophyll
Yuzu
Zinc
Zingerone

Products containing iridoids

We currently have no products on Vitabase that contain this ingredient.