Evidence supporting the use of: Iridoids
For the health condition: Migraine

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Iridoids are a class of secondary metabolites commonly found in several medicinal plants, such as feverfew (Tanacetum parthenium) and valerian (Valeriana officinalis). Their use in supporting or treating migraine is primarily rooted in traditional and folk medicine. For example, feverfew, which contains parthenolide (an iridoid derivative), has been traditionally used in Europe for centuries to prevent migraines and alleviate related symptoms. Some early clinical studies in the late 20th century suggested a potential benefit of feverfew in reducing migraine frequency, but these studies were often small and methodologically limited. More recent systematic reviews and meta-analyses have concluded that the evidence is inconsistent and not robust enough to conclusively support efficacy.

While iridoids have demonstrated anti-inflammatory and neuroprotective effects in preclinical studies, direct evidence linking iridoids themselves (as opposed to whole plant extracts) to migraine prevention or treatment in humans is sparse. Thus, the use of iridoid-containing plants for migraine is mostly justified by tradition rather than strong scientific validation.

In summary, iridoids are used for migraine support mainly due to longstanding traditional practices, with scientific evidence rated as weak or inconclusive (2/5).

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Products containing iridoids

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