Evidence supporting the use of: Iridoids
For the health condition: Migraine

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Iridoids are a class of secondary metabolites commonly found in several medicinal plants, such as feverfew (Tanacetum parthenium) and valerian (Valeriana officinalis). Their use in supporting or treating migraine is primarily rooted in traditional and folk medicine. For example, feverfew, which contains parthenolide (an iridoid derivative), has been traditionally used in Europe for centuries to prevent migraines and alleviate related symptoms. Some early clinical studies in the late 20th century suggested a potential benefit of feverfew in reducing migraine frequency, but these studies were often small and methodologically limited. More recent systematic reviews and meta-analyses have concluded that the evidence is inconsistent and not robust enough to conclusively support efficacy.

While iridoids have demonstrated anti-inflammatory and neuroprotective effects in preclinical studies, direct evidence linking iridoids themselves (as opposed to whole plant extracts) to migraine prevention or treatment in humans is sparse. Thus, the use of iridoid-containing plants for migraine is mostly justified by tradition rather than strong scientific validation.

In summary, iridoids are used for migraine support mainly due to longstanding traditional practices, with scientific evidence rated as weak or inconclusive (2/5).

More about iridoids
More about Migraine

Other ingredients used for Migraine

5-Hydroxytryptophan (5-HTP)
alpha-linolenic acid (ALA)
ashwagandha
bergamot
beta caryophyllene
black tea
Indian frankincense
bupleurum falcatum
Chinese salvia root
coenzyme Q10 (CoQ10)
turmeric
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
feverfew
fish oil
ginger
ginkgo biloba
gooseberry
gotu kola
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
luteolin
magnesium
melatonin
moringa
niacin (vitamin B3)
omega-3 fatty acids
Peppermint
phytocannabinoids
pine bark
purple butterbur root
riboflavin (vitamin B2)
specialized pro-resolving mediators (SPMs)
Almond fruit
ubiquinol
valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
zinc
atractylodes
blackboard tree
swertia
Szechuan lovage
chrysanthemum
soursop
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
Apple Cider Vinegar
Albizia
Alpha-Lipoic Acid
Atractylone
Betony
Black Seed
Baikal Skullcap
Beta-hydroxybutyrate
Blepharis
Balsam
Banyan
Brahmi
Butterbur
Bifidobacteria
Black Hellebore
Chinese Silkvine
Crocin
Creatine
Cannabidiol
Corydalis
Carthamus
cola nut
Docosahexaenoic Acid
Danshen
Eicosapentaenoic Acid
Folic Acid
Flavin mononucleotide
Ficus religiosa
Fish
Flavanones
Ficus simplicissima
Frankincense
Goldthread
Gelsemium
Ginkgolides
Ginkgoside
Hellebore
iridoids
Ketone Salts
Kuding tea
lemon balm
Lesser speargrass
Little ironweed
Linalool
Mesua
Methylxanthine
Meadowsweet
Nardostachys
Night jessamine
Osthole
Puerarin
Petasines
Phthalides
Paeoniflorin
Pycnogenol
Polygonum
Palmitoylethanolamide (PEA)
Rue
Rubus
Rauvolfia
Rubiaceae
Spikenard
Sensitive Plant
Salmon Oil
Sandalwood
Scabrous Gentian
Uncaria
Withanolides
Xanthine
Xanthophyll
Xanthone
Yuzu
Zingerone

Products containing iridoids

We currently have no products on Vitabase that contain this ingredient.