Evidence supporting the use of: Ketone salts
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ketone salts have recently been investigated for their potential role in migraine management, based on emerging scientific evidence rather than long-standing traditional use. Migraine has been linked to metabolic dysfunction and impaired brain energy metabolism. The ketogenic diet, which elevates blood ketone levels, has shown some efficacy in reducing migraine frequency and severity in preliminary studies. Ketone salts are supplements that provide exogenous ketones (usually beta-hydroxybutyrate) and can raise blood ketone levels without requiring strict dietary changes.

Small pilot studies and case reports suggest that exogenous ketones may help reduce migraine frequency and improve symptoms, possibly by providing an alternative energy source for neurons, reducing neuroinflammation, or modulating neurotransmitter systems. For example, a 2020 pilot study (Di Lorenzo et al.) found that exogenous ketone supplementation reduced migraine days in a group of patients. However, the total number of participants in such studies is small, and research is still at an early stage. No large-scale, high-quality randomized controlled trials have yet confirmed the efficacy of ketone salts for migraine, and the optimal dosing and long-term safety remain uncertain.

In summary, the use of ketone salts for migraine is grounded in recent scientific hypotheses and early clinical evidence, but the overall quality and quantity of evidence is currently low, justifying a rating of 2 out of 5.

More about ketone salts
More about Migraine

Other ingredients used for Migraine

1,3,7-Trimethylpurine-2,6-dione
5-Hydroxytryptophan (5-HTP)
5-methyltetrahydrofolate glucosamine
Albizia
Almond fruit
alpha-linolenic acid (ALA)
alpha-lipoic acid
apple cider vinegar
ashwagandha
atractylodes
atractylone
Baikal Skullcap
balsam
banyan
bergamot
beta caryophyllene
beta-hydroxybutyrate
betony
Bifidobacteria
Black Hellebore
black seed
black tea
blackboard tree
Blepharis
brahmi
bupleurum falcatum
butterbur
cannabidiol
Carthamus
Chinese salvia root
Chinese silkvine
chrysanthemum
coenzyme Q10 (CoQ10)
cola nut
Corydalis
creatine
crocin
curcumin
danshen
DHA (docosahexaenoic acid)
docosahexaenoic Acid
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
feverfew
Ficus religiosa
Ficus simplicissima
fish
fish oil
flavanones
flavin mononucleotide
folic acid
frankincense
Gelsemium
ginger
ginkgo biloba
ginkgolides
Ginkgoside
goldthread
gooseberry
gotu kola
Hellebore
Indian frankincense
iridoids
ketone salts
kuding tea
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
lemon balm
Lesser speargrass
linalool
little ironweed
luteolin
magnesium
Meadowsweet
Melatonin
Mesua
Methylxanthine
Moringa
Nardostachys
Niacin (vitamin B3)
Night jessamine
omega-3 fatty acids
Osthole
paeoniflorin
Palmitoylethanolamide (PEA)
Peppermint
Petasines
Phthalides
phytocannabinoids
pine bark
Polygonum
Puerarin
purple butterbur root
Pycnogenol
Rauvolfia
riboflavin (vitamin B2)
Rubiaceae
Rubus
rue
Salmon Oil
Sandalwood
Scabrous Gentian
Sensitive Plant
soursop
specialized pro-resolving mediators (SPMs)
Spikenard
Swertia
Szechuan lovage
turmeric
ubiquinol
Uncaria
Valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
Withanolides
Xanthine
Xanthone
Xanthophyll
Yuzu
Zinc
Zingerone

Products containing ketone salts

We currently have no products on Vitabase that contain this ingredient.