Evidence supporting the use of: Little ironweed
For the health condition: Migraine

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Little ironweed (Vernonia cinerea) is traditionally used in various systems of folk medicine in Asia and Africa, including Ayurveda, to address a range of ailments, among them headaches and migraine-like symptoms. Traditional healers have employed preparations from the plant—such as decoctions or infusions of its leaves or flowers—for their purported analgesic and anti-inflammatory properties. This ethnobotanical use is primarily based on the observation and transmission of healing practices across generations rather than rigorous, controlled scientific studies.

A limited number of laboratory investigations have shown that extracts of Vernonia cinerea possess anti-inflammatory and analgesic effects in animal models, which could rationalize its use for headache disorders. However, direct clinical evidence or high-quality human trials specifically evaluating its efficacy for migraine is lacking. The available scientific literature does not provide robust, direct validation for its effectiveness against migraine in humans. Therefore, the use of Little ironweed for migraine remains grounded more in traditional practice than in modern clinical evidence, meriting an evidence rating of 2.

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