Magnesium supplementation, including forms like magnesium citrate and magnesium malate, is used to support migraine prevention based on a growing body of scientific evidence. Several clinical studies and meta-analyses have shown that people with migraines often have lower magnesium levels in the brain and serum compared to those without migraines. Magnesium plays a role in neuronal excitability, neurotransmitter release, and vascular tone, all of which are implicated in migraine pathophysiology.

Randomized controlled trials have demonstrated that magnesium supplementation (commonly in the form of magnesium oxide, but also other bioavailable salts like citrate or malate) can reduce the frequency and intensity of migraine attacks, particularly in individuals with documented magnesium deficiency or menstrual migraines. The American Headache Society and American Academy of Neurology consider magnesium as a "probably effective" option for migraine prevention.

Magnesium citrate malate specifically is not as extensively studied as magnesium oxide or citrate alone, but it is a highly bioavailable form, suggesting that it could be effective for increasing systemic magnesium levels. Its use is thus supported by extrapolation from studies on magnesium in general, rather than direct evidence for this precise compound.

In summary, scientific evidence supports the use of magnesium supplementation for migraine prevention, though most studies have not focused on magnesium citrate malate specifically. The overall evidence level for magnesium in migraine is moderate.