Evidence supporting the use of: Melatonin
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Melatonin is increasingly studied as a potential treatment for migraine, with mounting scientific evidence supporting its efficacy, though it is not yet considered a first-line therapy. Melatonin is a hormone naturally produced by the pineal gland, primarily involved in regulating sleep-wake cycles. Migraine attacks have been associated with disruptions in circadian rhythms and sleep patterns, both of which are influenced by melatonin. Several clinical studies and randomized controlled trials (RCTs) have evaluated the role of melatonin supplementation in migraine prevention. For example, a well-cited 2016 double-blind RCT published in Neurology found that 3 mg of melatonin was as effective as amitriptyline (a standard migraine preventive medication) and better than placebo in reducing migraine frequency, with fewer side effects.

Meta-analyses also suggest that melatonin may decrease the frequency, intensity, and duration of migraine attacks when used prophylactically. The proposed mechanisms include its antioxidant, anti-inflammatory, and analgesic effects, as well as its ability to stabilize circadian rhythms. Despite these promising findings, larger and longer-term studies are needed to confirm optimal dosing, safety, and efficacy. Melatonin is generally well-tolerated and may be particularly useful in patients with comorbid sleep disorders. In summary, while melatonin is not universally recommended in migraine guidelines yet, its use is scientifically substantiated with moderate-quality evidence, warranting a rating of 3 out of 5.

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Other ingredients used for Migraine

1,3,7-Trimethylpurine-2,6-dione
5-Hydroxytryptophan (5-HTP)
5-methyltetrahydrofolate glucosamine
Albizia
Almond fruit
alpha-linolenic acid (ALA)
alpha-lipoic acid
apple cider vinegar
ashwagandha
atractylodes
atractylone
Baikal Skullcap
balsam
banyan
bergamot
beta caryophyllene
beta-hydroxybutyrate
betony
Bifidobacteria
Black Hellebore
black seed
black tea
blackboard tree
Blepharis
brahmi
bupleurum falcatum
butterbur
cannabidiol
Carthamus
Chinese salvia root
Chinese silkvine
chrysanthemum
coenzyme Q10 (CoQ10)
cola nut
Corydalis
creatine
crocin
curcumin
danshen
DHA (docosahexaenoic acid)
docosahexaenoic Acid
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
feverfew
Ficus religiosa
Ficus simplicissima
fish
fish oil
flavanones
flavin mononucleotide
folic acid
frankincense
Gelsemium
ginger
ginkgo biloba
ginkgolides
Ginkgoside
goldthread
gooseberry
gotu kola
Hellebore
Indian frankincense
iridoids
ketone salts
kuding tea
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
lemon balm
Lesser speargrass
linalool
little ironweed
luteolin
magnesium
Meadowsweet
Melatonin
Mesua
Methylxanthine
Moringa
Nardostachys
Niacin (vitamin B3)
Night jessamine
omega-3 fatty acids
Osthole
paeoniflorin
Palmitoylethanolamide (PEA)
Peppermint
Petasines
Phthalides
phytocannabinoids
pine bark
Polygonum
Puerarin
purple butterbur root
Pycnogenol
Rauvolfia
riboflavin (vitamin B2)
Rubiaceae
Rubus
rue
Salmon Oil
Sandalwood
Scabrous Gentian
Sensitive Plant
soursop
specialized pro-resolving mediators (SPMs)
Spikenard
Swertia
Szechuan lovage
turmeric
ubiquinol
Uncaria
Valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
Withanolides
Xanthine
Xanthone
Xanthophyll
Yuzu
Zinc
Zingerone