Evidence supporting the use of: Paeoniflorin
For the health condition: Migraine

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Paeoniflorin is a major bioactive compound extracted from the root of Paeonia lactiflora (white peony), a plant widely used in traditional Chinese medicine (TCM). Its use for headaches, including migraine, is rooted mainly in traditional practices rather than strong scientific validation. In TCM, formulas containing paeoniflorin (such as Chuanxiong Chatiao San and others) have historically been used to "soothe the liver," "harmonize the blood," and alleviate various types of pain, including headaches, which can encompass migraine-like symptoms.

Modern scientific research on paeoniflorin’s effects on migraine is limited. A few preclinical studies suggest anti-inflammatory, neuroprotective, and vasodilatory properties, which are mechanisms potentially relevant to migraine pathophysiology. For example, paeoniflorin has been shown to inhibit the release of inflammatory cytokines and modulate nitric oxide pathways in animal models. However, there are no large-scale, high-quality human clinical trials directly examining paeoniflorin or paeony extracts specifically for migraine treatment or prevention.

Overall, while traditional use for headache and migraine-like symptoms is well documented, scientific evidence supporting the efficacy of paeoniflorin for migraine is weak and preliminary. Thus, its use is primarily justified by tradition, with limited supportive scientific data.

More about Paeoniflorin
More about Migraine

Products containing Paeoniflorin

We currently have no products on Vitabase that contain this ingredient.