Evidence supporting the use of: Paeoniflorin
For the health condition: Migraine

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Paeoniflorin is a major bioactive compound extracted from the root of Paeonia lactiflora (white peony), a plant widely used in traditional Chinese medicine (TCM). Its use for headaches, including migraine, is rooted mainly in traditional practices rather than strong scientific validation. In TCM, formulas containing paeoniflorin (such as Chuanxiong Chatiao San and others) have historically been used to "soothe the liver," "harmonize the blood," and alleviate various types of pain, including headaches, which can encompass migraine-like symptoms.

Modern scientific research on paeoniflorin’s effects on migraine is limited. A few preclinical studies suggest anti-inflammatory, neuroprotective, and vasodilatory properties, which are mechanisms potentially relevant to migraine pathophysiology. For example, paeoniflorin has been shown to inhibit the release of inflammatory cytokines and modulate nitric oxide pathways in animal models. However, there are no large-scale, high-quality human clinical trials directly examining paeoniflorin or paeony extracts specifically for migraine treatment or prevention.

Overall, while traditional use for headache and migraine-like symptoms is well documented, scientific evidence supporting the efficacy of paeoniflorin for migraine is weak and preliminary. Thus, its use is primarily justified by tradition, with limited supportive scientific data.

More about paeoniflorin
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Other ingredients used for Migraine

1,3,7-Trimethylpurine-2,6-dione
5-Hydroxytryptophan (5-HTP)
5-methyltetrahydrofolate glucosamine
Albizia
Almond fruit
alpha-linolenic acid (ALA)
alpha-lipoic acid
apple cider vinegar
ashwagandha
atractylodes
atractylone
Baikal Skullcap
balsam
banyan
bergamot
beta caryophyllene
beta-hydroxybutyrate
betony
Bifidobacteria
Black Hellebore
black seed
black tea
blackboard tree
Blepharis
brahmi
bupleurum falcatum
butterbur
cannabidiol
Carthamus
Chinese salvia root
Chinese silkvine
chrysanthemum
coenzyme Q10 (CoQ10)
cola nut
Corydalis
creatine
crocin
curcumin
danshen
DHA (docosahexaenoic acid)
docosahexaenoic Acid
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
feverfew
Ficus religiosa
Ficus simplicissima
fish
fish oil
flavanones
flavin mononucleotide
folic acid
frankincense
Gelsemium
ginger
ginkgo biloba
ginkgolides
Ginkgoside
goldthread
gooseberry
gotu kola
Hellebore
Indian frankincense
iridoids
ketone salts
kuding tea
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
lemon balm
Lesser speargrass
linalool
little ironweed
luteolin
magnesium
Meadowsweet
Melatonin
Mesua
Methylxanthine
Moringa
Nardostachys
Niacin (vitamin B3)
Night jessamine
omega-3 fatty acids
Osthole
paeoniflorin
Palmitoylethanolamide (PEA)
Peppermint
Petasines
Phthalides
phytocannabinoids
pine bark
Polygonum
Puerarin
purple butterbur root
Pycnogenol
Rauvolfia
riboflavin (vitamin B2)
Rubiaceae
Rubus
rue
Salmon Oil
Sandalwood
Scabrous Gentian
Sensitive Plant
soursop
specialized pro-resolving mediators (SPMs)
Spikenard
Swertia
Szechuan lovage
turmeric
ubiquinol
Uncaria
Valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
Withanolides
Xanthine
Xanthone
Xanthophyll
Yuzu
Zinc
Zingerone

Products containing paeoniflorin

We currently have no products on Vitabase that contain this ingredient.