Evidence supporting the use of: Paeoniflorin
For the health condition: Migraine

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Paeoniflorin is a major bioactive compound extracted from the root of Paeonia lactiflora (white peony), a plant widely used in traditional Chinese medicine (TCM). Its use for headaches, including migraine, is rooted mainly in traditional practices rather than strong scientific validation. In TCM, formulas containing paeoniflorin (such as Chuanxiong Chatiao San and others) have historically been used to "soothe the liver," "harmonize the blood," and alleviate various types of pain, including headaches, which can encompass migraine-like symptoms.

Modern scientific research on paeoniflorin’s effects on migraine is limited. A few preclinical studies suggest anti-inflammatory, neuroprotective, and vasodilatory properties, which are mechanisms potentially relevant to migraine pathophysiology. For example, paeoniflorin has been shown to inhibit the release of inflammatory cytokines and modulate nitric oxide pathways in animal models. However, there are no large-scale, high-quality human clinical trials directly examining paeoniflorin or paeony extracts specifically for migraine treatment or prevention.

Overall, while traditional use for headache and migraine-like symptoms is well documented, scientific evidence supporting the efficacy of paeoniflorin for migraine is weak and preliminary. Thus, its use is primarily justified by tradition, with limited supportive scientific data.

More about Paeoniflorin
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Other ingredients used for Migraine

5-Hydroxytryptophan (5-HTP)
alpha-linolenic acid (ALA)
ashwagandha
bergamot
beta caryophyllene
black tea
Indian frankincense
bupleurum falcatum
Chinese salvia root
coenzyme Q10 (CoQ10)
turmeric
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
feverfew
fish oil
ginger
ginkgo biloba
gooseberry
gotu kola
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
luteolin
magnesium
melatonin
moringa
niacin (vitamin B3)
omega-3 fatty acids
Peppermint
phytocannabinoids
pine bark
purple butterbur root
riboflavin (vitamin B2)
specialized pro-resolving mediators (SPMs)
Almond fruit
ubiquinol
valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
zinc
atractylodes
blackboard tree
swertia
Szechuan lovage
chrysanthemum
soursop
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
Apple Cider Vinegar
Albizia
Alpha-Lipoic Acid
Atractylone
Betony
Black Seed
Baikal Skullcap
Beta-hydroxybutyrate
Blepharis
Balsam
Banyan
Brahmi
Butterbur
Bifidobacteria
Black Hellebore
Chinese Silkvine
Crocin
Creatine
Cannabidiol
Corydalis
Carthamus
cola nut
Docosahexaenoic Acid
Danshen
Eicosapentaenoic Acid
Folic Acid
Flavin mononucleotide
Ficus religiosa
Fish
Flavanones
Ficus simplicissima
Frankincense
Goldthread
Gelsemium
Ginkgolides
Ginkgoside
Hellebore
iridoids
Ketone Salts
Kuding tea
lemon balm
Lesser speargrass
Little ironweed
Linalool
Mesua
Methylxanthine
Meadowsweet
Nardostachys
Night jessamine
Osthole
Puerarin
Petasines
Phthalides
Paeoniflorin
Pycnogenol
Polygonum
Palmitoylethanolamide (PEA)
Rue
Rubus
Rauvolfia
Rubiaceae
Spikenard
Sensitive Plant
Salmon Oil
Sandalwood
Scabrous Gentian
Uncaria
Withanolides
Xanthine
Xanthophyll
Xanthone
Yuzu
Zingerone

Products containing Paeoniflorin

We currently have no products on Vitabase that contain this ingredient.