Evidence supporting the use of: Phthalides
For the health condition: Migraine

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Phthalides are a group of natural compounds predominantly found in certain medicinal plants, most notably Ligusticum chuanxiong (Szechuan lovage) and celery. Their use in supporting or treating migraine is primarily rooted in traditional Chinese medicine (TCM), where extracts from these plants have long been used to address headaches and related vascular disorders. In TCM, Ligusticum chuanxiong is a classic remedy included in formulations such as "Chuanxiong Chatiao San" for the relief of headaches, including migraines.

While there is some laboratory and preclinical evidence indicating that phthalides may exert vasodilatory, anti-inflammatory, and neuroprotective effects, robust clinical evidence in humans remains limited. A few small-scale studies and reviews suggest that extracts containing phthalides may help modulate blood flow and reduce neurogenic inflammation, which are relevant mechanisms in migraine pathology. However, these findings are preliminary and do not rise to the level of large, high-quality randomized controlled trials.

Overall, the use of phthalides for migraines is justified more by traditional use and empirical application rather than by a strong base of scientific validation. Therefore, the evidence supporting its use in migraine treatment is rated as 2 out of 5, reflecting limited but suggestive data, and a reliance on historical practice.

More about Phthalides
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Products containing Phthalides

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