Evidence supporting the use of: Phytocannabinoid (unspecified)
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Phytocannabinoids, particularly those derived from the Cannabis sativa plant such as cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC), have been investigated for their potential in managing migraine. Historically, cannabis preparations were used in the 19th and early 20th centuries for headache relief, but modern scientific inquiry has provided a more structured evaluation of their efficacy. Several observational studies and small clinical trials suggest that phytocannabinoids may reduce the frequency and severity of migraine attacks in some individuals, possibly through modulation of the endocannabinoid system, which is involved in pain processing, inflammation, and neurotransmitter regulation.

However, the quality and quantity of evidence remain limited. Reviews, such as those published in Frontiers in Pharmacology (2018) and Current Pain and Headache Reports (2020), note promising findings but emphasize the lack of large, high-quality randomized controlled trials (RCTs). Dosing, cannabinoid composition, and long-term safety are not well established for migraine treatment. The American Headache Society does not currently recommend cannabinoids as a first-line therapy due to insufficient evidence.

In summary, while there is a scientific rationale and some supportive clinical data for the use of phytocannabinoids in migraine, the overall strength of the evidence is moderate at best (rated 3/5), and further research is necessary to establish efficacy, safety, and guidelines for clinical use.

More about Phytocannabinoid (unspecified)
More about Migraine

Other ingredients used for Migraine

5-Hydroxytryptophan (5-HTP)
alpha-linolenic acid (ALA)
ashwagandha
bergamot
beta caryophyllene
black tea
Indian frankincense
bupleurum falcatum
Chinese salvia root
coenzyme Q10 (CoQ10)
turmeric
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
feverfew
fish oil
ginger
ginkgo biloba
gooseberry
gotu kola
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
luteolin
magnesium
melatonin
moringa
niacin (vitamin B3)
omega-3 fatty acids
Peppermint
phytocannabinoids
pine bark
purple butterbur root
riboflavin (vitamin B2)
specialized pro-resolving mediators (SPMs)
Almond fruit
ubiquinol
valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
zinc
atractylodes
blackboard tree
swertia
Szechuan lovage
chrysanthemum
soursop
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
Apple Cider Vinegar
Albizia
Alpha-Lipoic Acid
Atractylone
Betony
Black Seed
Baikal Skullcap
Beta-hydroxybutyrate
Blepharis
Balsam
Banyan
Brahmi
Butterbur
Bifidobacteria
Black Hellebore
Chinese Silkvine
Crocin
Creatine
Cannabidiol
Corydalis
Carthamus
cola nut
Docosahexaenoic Acid
Danshen
Eicosapentaenoic Acid
Folic Acid
Flavin mononucleotide
Ficus religiosa
Fish
Flavanones
Ficus simplicissima
Frankincense
Goldthread
Gelsemium
Ginkgolides
Ginkgoside
Hellebore
iridoids
Ketone Salts
Kuding tea
lemon balm
Lesser speargrass
Little ironweed
Linalool
Mesua
Methylxanthine
Meadowsweet
Nardostachys
Night jessamine
Osthole
Puerarin
Petasines
Phthalides
Paeoniflorin
Pycnogenol
Polygonum
Palmitoylethanolamide (PEA)
Rue
Rubus
Rauvolfia
Rubiaceae
Spikenard
Sensitive Plant
Salmon Oil
Sandalwood
Scabrous Gentian
Uncaria
Withanolides
Xanthine
Xanthophyll
Xanthone
Yuzu
Zingerone

Products containing Phytocannabinoid (unspecified)

We currently have no products on Vitabase that contain this ingredient.