Evidence supporting the use of: Polyunsaturated fatty acid
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Polyunsaturated fatty acids (PUFAs), particularly omega-3 fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been investigated for their potential role in migraine prevention and treatment. The rationale is grounded in the anti-inflammatory properties of these fatty acids, as inflammation is implicated in migraine pathophysiology. Several clinical trials and systematic reviews have assessed the efficacy of omega-3 supplementation in reducing migraine frequency, duration, and intensity. Results are mixed: Some studies report modest benefits, such as reduced migraine days or headache severity, while others find no significant difference compared to placebo. For example, a 2021 randomized controlled trial published in BMJ found that a diet high in omega-3s and low in omega-6s reduced headache frequency and severity in chronic headache sufferers, including those with migraine. However, meta-analyses note that the overall quality of evidence is moderate, and heterogeneity among studies limits definitive conclusions. Guidelines from major headache societies do not universally recommend PUFAs as first-line therapy, but acknowledge their potential as adjunctive treatment. In summary, there is scientific investigation and some supportive evidence for PUFAs in migraine, but the strength of evidence is moderate and further high-quality research is needed to clarify their role.

More about Polyunsaturated fatty acid
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Other ingredients used for Migraine

5-Hydroxytryptophan (5-HTP)
alpha-linolenic acid (ALA)
ashwagandha
bergamot
beta caryophyllene
black tea
Indian frankincense
bupleurum falcatum
Chinese salvia root
coenzyme Q10 (CoQ10)
turmeric
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
feverfew
fish oil
ginger
ginkgo biloba
gooseberry
gotu kola
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
luteolin
magnesium
melatonin
moringa
niacin (vitamin B3)
omega-3 fatty acids
Peppermint
phytocannabinoids
pine bark
purple butterbur root
riboflavin (vitamin B2)
specialized pro-resolving mediators (SPMs)
Almond fruit
ubiquinol
valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
zinc
atractylodes
blackboard tree
swertia
Szechuan lovage
chrysanthemum
soursop
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
Apple Cider Vinegar
Albizia
Alpha-Lipoic Acid
Atractylone
Betony
Black Seed
Baikal Skullcap
Beta-hydroxybutyrate
Blepharis
Balsam
Banyan
Brahmi
Butterbur
Bifidobacteria
Black Hellebore
Chinese Silkvine
Crocin
Creatine
Cannabidiol
Corydalis
Carthamus
cola nut
Docosahexaenoic Acid
Danshen
Eicosapentaenoic Acid
Folic Acid
Flavin mononucleotide
Ficus religiosa
Fish
Flavanones
Ficus simplicissima
Frankincense
Goldthread
Gelsemium
Ginkgolides
Ginkgoside
Hellebore
iridoids
Ketone Salts
Kuding tea
lemon balm
Lesser speargrass
Little ironweed
Linalool
Mesua
Methylxanthine
Meadowsweet
Nardostachys
Night jessamine
Osthole
Puerarin
Petasines
Phthalides
Paeoniflorin
Pycnogenol
Polygonum
Palmitoylethanolamide (PEA)
Rue
Rubus
Rauvolfia
Rubiaceae
Spikenard
Sensitive Plant
Salmon Oil
Sandalwood
Scabrous Gentian
Uncaria
Withanolides
Xanthine
Xanthophyll
Xanthone
Yuzu
Zingerone

Products containing Polyunsaturated fatty acid

We currently have no products on Vitabase that contain this ingredient.