Evidence supporting the use of: Potassium Beta-Hydroxybutyrate
For the health condition: Migraine
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Potassium Beta-Hydroxybutyrate (BHB) is a ketone body salt used as an exogenous ketone supplement. Its use in supporting or treating migraine is based on emerging scientific evidence related to the neurological effects of ketosis. Several small clinical studies and case reports have investigated the potential benefit of ketogenic diets and exogenous ketone supplementation, including BHB, in migraine management. The proposed mechanism involves improved mitochondrial function, reduced neuronal excitability, and altered neurotransmitter balance, all of which may play roles in migraine pathophysiology.
A 2021 randomized controlled trial (Pediatric Neurology, 2021) found that exogenous ketone supplementation reduced migraine frequency in adolescents, though the study size was small. Additional studies of ketogenic diets (which increase endogenous BHB) have shown reductions in migraine frequency and severity, suggesting a role for ketone bodies in modulating migraine activity. However, direct evidence from large, high-quality randomized trials specifically studying Potassium BHB as a supplement for migraine is limited. Most current data comes from pilot studies, case series, or extrapolation from ketogenic diet research.
In summary, there is preliminary scientific validation for the use of Potassium Beta-Hydroxybutyrate in migraine, but the overall quality and quantity of evidence are moderate. Larger, well-controlled studies are needed to confirm efficacy and establish dosing guidelines.
More about Potassium Beta-Hydroxybutyrate
More about Migraine
Other ingredients used for Migraine
5-Hydroxytryptophan (5-HTP)alpha-linolenic acid (ALA)
ashwagandha
bergamot
beta caryophyllene
black tea
Indian frankincense
bupleurum falcatum
Chinese salvia root
coenzyme Q10 (CoQ10)
turmeric
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
feverfew
fish oil
ginger
ginkgo biloba
gooseberry
gotu kola
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
luteolin
magnesium
melatonin
moringa
niacin (vitamin B3)
omega-3 fatty acids
Peppermint
phytocannabinoids
pine bark
purple butterbur root
riboflavin (vitamin B2)
specialized pro-resolving mediators (SPMs)
Almond fruit
ubiquinol
valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
zinc
atractylodes
blackboard tree
swertia
Szechuan lovage
chrysanthemum
soursop
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
Apple Cider Vinegar
Albizia
Alpha-Lipoic Acid
Atractylone
Betony
Black Seed
Baikal Skullcap
Beta-hydroxybutyrate
Blepharis
Balsam
Banyan
Brahmi
Butterbur
Bifidobacteria
Black Hellebore
Chinese Silkvine
Crocin
Creatine
Cannabidiol
Corydalis
Carthamus
cola nut
Docosahexaenoic Acid
Danshen
Eicosapentaenoic Acid
Folic Acid
Flavin mononucleotide
Ficus religiosa
Fish
Flavanones
Ficus simplicissima
Frankincense
Goldthread
Gelsemium
Ginkgolides
Ginkgoside
Hellebore
iridoids
Ketone Salts
Kuding tea
lemon balm
Lesser speargrass
Little ironweed
Linalool
Mesua
Methylxanthine
Meadowsweet
Nardostachys
Night jessamine
Osthole
Puerarin
Petasines
Phthalides
Paeoniflorin
Pycnogenol
Polygonum
Palmitoylethanolamide (PEA)
Rue
Rubus
Rauvolfia
Rubiaceae
Spikenard
Sensitive Plant
Salmon Oil
Sandalwood
Scabrous Gentian
Uncaria
Withanolides
Xanthine
Xanthophyll
Xanthone
Yuzu
Zingerone
Other health conditions supported by Potassium Beta-Hydroxybutyrate
Alzheimer's DiseaseAthletic and Exercise Aids
Energy (lack of)
Fatigue
Inflammation
Metabolic Syndrome
Migraine
Weight Loss