Evidence supporting the use of: Rubiaceae (unspecified)
For the health condition: Migraine

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Synopsis

Source of validity: Traditional
Rating (out of 5): 1

The use of Rubiaceae family plants for the treatment of migraine is primarily rooted in traditional medicine systems rather than robust scientific evidence. Several genera within Rubiaceae, such as Coffea (coffee) and Cinchona (source of quinine), have a history of medicinal use, but specific references to their use for migraine are largely ethnobotanical and anecdotal. For example, in some traditional practices, extracts from Rubia (madder), Morinda, or other Rubiaceae members have been used for general pain relief or as anti-inflammatory agents, which could be extrapolated to headache or migraine treatment. However, these uses are based on historical herbal medicine records and local traditions rather than controlled clinical studies.

There is limited preclinical research suggesting that some Rubiaceae species contain compounds with potential anti-inflammatory or analgesic properties, but these findings are not directly linked to migraine management, and no high-quality clinical trials have established efficacy or safety for this indication. In summary, while there is a traditional basis for using certain Rubiaceae plants for headaches or migraine-like symptoms, the scientific evidence remains weak, justifying a low evidence rating.

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