Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Ubiquinol, the reduced and active form of coenzyme Q10 (CoQ10), is used to support and treat migraines based on emerging scientific evidence. Several randomized controlled trials have investigated the efficacy of coenzyme Q10 (in both ubiquinol and ubiquinone forms) for migraine prevention. The rationale for its use is rooted in the observation that mitochondrial dysfunction may play a role in migraine pathophysiology. CoQ10 is essential for mitochondrial energy production and acts as an antioxidant, potentially addressing these dysfunctions. A notable double-blind, placebo-controlled trial published in Neurology (2005) found that CoQ10 supplementation reduced the frequency of migraine attacks compared to placebo. Later studies have confirmed these findings, suggesting that CoQ10 is effective and well-tolerated as a preventive therapy. The Canadian Headache Society and the American Academy of Neurology have both listed CoQ10 as a possible option for migraine prophylaxis, with a low risk of side effects. While most studies have used the ubiquinone form, some recent evidence suggests that ubiquinol, as the active form, may offer better bioavailability, although direct comparative studies are limited. Overall, the scientific evidence supporting ubiquinol (and CoQ10 in general) for migraine prevention is moderate, justifying a rating of 3/5. Larger and longer-term studies are warranted to firmly establish its efficacy and optimal dosing.

More about ubiquinol
More about Migraine

Other ingredients used for Migraine

Other health conditions supported by ubiquinol

Products containing ubiquinol

Designs For Health COQ200 200mg
Designs For Health CoQnol™ 100mg
Douglas Laboratories Ubiquinol-QH
Douglas Laboratories Ubiquinol-QH