Evidence supporting the use of: Unsaturated fatty acid
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Unsaturated fatty acids, particularly omega-3 fatty acids (such as EPA and DHA found in fish oil), have been investigated for their potential role in migraine management. Scientific interest stems from their anti-inflammatory properties and modulation of neuronal function. Several clinical studies and meta-analyses have explored the relationship between dietary intake or supplementation of omega-3 fatty acids and migraine frequency, duration, and severity. For example, a randomized controlled trial published in 2021 in the journal BMJ found that a diet higher in omega-3 and lower in omega-6 fatty acids led to a reduction in headache frequency and intensity among chronic migraine sufferers. Another meta-analysis in Headache (2020) suggested modest benefit from omega-3 supplementation in reducing migraine days, though results across studies are variable and sometimes inconclusive.

The biological rationale centers on the ability of unsaturated fatty acids to alter the production of inflammatory mediators (such as prostaglandins and leukotrienes) implicated in migraine pathophysiology. While the evidence is not uniformly strong and more high-quality, large-scale trials are needed, current data provide moderate scientific support for the use of unsaturated fatty acids—especially omega-3s—as adjunctive therapy in migraine prevention. They are not a first-line therapy but may be recommended as part of a holistic approach for some patients.

More about Unsaturated fatty acid
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Other ingredients used for Migraine

5-Hydroxytryptophan (5-HTP)
alpha-linolenic acid (ALA)
ashwagandha
bergamot
beta caryophyllene
black tea
Indian frankincense
bupleurum falcatum
Chinese salvia root
coenzyme Q10 (CoQ10)
turmeric
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
feverfew
fish oil
ginger
ginkgo biloba
gooseberry
gotu kola
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
luteolin
magnesium
melatonin
moringa
niacin (vitamin B3)
omega-3 fatty acids
Peppermint
phytocannabinoids
pine bark
purple butterbur root
riboflavin (vitamin B2)
specialized pro-resolving mediators (SPMs)
Almond fruit
ubiquinol
valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
zinc
atractylodes
blackboard tree
swertia
Szechuan lovage
chrysanthemum
soursop
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
Apple Cider Vinegar
Albizia
Alpha-Lipoic Acid
Atractylone
Betony
Black Seed
Baikal Skullcap
Beta-hydroxybutyrate
Blepharis
Balsam
Banyan
Brahmi
Butterbur
Bifidobacteria
Black Hellebore
Chinese Silkvine
Crocin
Creatine
Cannabidiol
Corydalis
Carthamus
cola nut
Docosahexaenoic Acid
Danshen
Eicosapentaenoic Acid
Folic Acid
Flavin mononucleotide
Ficus religiosa
Fish
Flavanones
Ficus simplicissima
Frankincense
Goldthread
Gelsemium
Ginkgolides
Ginkgoside
Hellebore
iridoids
Ketone Salts
Kuding tea
lemon balm
Lesser speargrass
Little ironweed
Linalool
Mesua
Methylxanthine
Meadowsweet
Nardostachys
Night jessamine
Osthole
Puerarin
Petasines
Phthalides
Paeoniflorin
Pycnogenol
Polygonum
Palmitoylethanolamide (PEA)
Rue
Rubus
Rauvolfia
Rubiaceae
Spikenard
Sensitive Plant
Salmon Oil
Sandalwood
Scabrous Gentian
Uncaria
Withanolides
Xanthine
Xanthophyll
Xanthone
Yuzu
Zingerone

Products containing Unsaturated fatty acid

We currently have no products on Vitabase that contain this ingredient.