Evidence supporting the use of: Vitamin B2 (riboflavin 5-phosphate)
For the health condition: Migraine
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Vitamin B2 (riboflavin 5-phosphate) is used to support or treat migraines based on scientific evidence, particularly for migraine prevention. Several clinical studies have investigated the potential of riboflavin as a prophylactic agent for migraine, primarily due to its role in mitochondrial energy metabolism. Research suggests that migraines may be linked to mitochondrial dysfunction, and riboflavin is an important cofactor in the mitochondrial electron transport chain. By improving mitochondrial function, riboflavin may help reduce the frequency and severity of migraine attacks.
A notable randomized controlled trial published in Neurology (1998) found that 400 mg of riboflavin daily significantly reduced migraine frequency in adults compared to placebo. Subsequent studies and meta-analyses have supported these findings, although results for efficacy in children and adolescents are less consistent. Riboflavin is recommended in several clinical guidelines, such as those from the American Academy of Neurology and the Canadian Headache Society, as an option for migraine prevention, particularly in adults.
Riboflavin is generally well tolerated, with minimal side effects (mainly harmless yellow discoloration of urine). While the exact mechanism is not fully understood, its favorable safety profile and evidence from multiple controlled studies justify its use as a non-prescription preventive strategy for migraines.
More about Vitamin B2 (riboflavin 5-phosphate)
More about Migraine
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ashwagandha
bergamot
beta caryophyllene
black tea
Indian frankincense
bupleurum falcatum
Chinese salvia root
coenzyme Q10 (CoQ10)
turmeric
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
feverfew
fish oil
ginger
ginkgo biloba
gooseberry
gotu kola
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
luteolin
magnesium
melatonin
moringa
niacin (vitamin B3)
omega-3 fatty acids
Peppermint
phytocannabinoids
pine bark
purple butterbur root
riboflavin (vitamin B2)
specialized pro-resolving mediators (SPMs)
Almond fruit
ubiquinol
valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
zinc
atractylodes
blackboard tree
swertia
Szechuan lovage
chrysanthemum
soursop
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
Apple Cider Vinegar
Albizia
Alpha-Lipoic Acid
Atractylone
Betony
Black Seed
Baikal Skullcap
Beta-hydroxybutyrate
Blepharis
Balsam
Banyan
Brahmi
Butterbur
Bifidobacteria
Black Hellebore
Chinese Silkvine
Crocin
Creatine
Cannabidiol
Corydalis
Carthamus
cola nut
Docosahexaenoic Acid
Danshen
Eicosapentaenoic Acid
Folic Acid
Flavin mononucleotide
Ficus religiosa
Fish
Flavanones
Ficus simplicissima
Frankincense
Goldthread
Gelsemium
Ginkgolides
Ginkgoside
Hellebore
iridoids
Ketone Salts
Kuding tea
lemon balm
Lesser speargrass
Little ironweed
Linalool
Mesua
Methylxanthine
Meadowsweet
Nardostachys
Night jessamine
Osthole
Puerarin
Petasines
Phthalides
Paeoniflorin
Pycnogenol
Polygonum
Palmitoylethanolamide (PEA)
Rue
Rubus
Rauvolfia
Rubiaceae
Spikenard
Sensitive Plant
Salmon Oil
Sandalwood
Scabrous Gentian
Uncaria
Withanolides
Xanthine
Xanthophyll
Xanthone
Yuzu
Zingerone