Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B2 (riboflavin) is supported by scientific evidence for use in migraine prophylaxis. Clinical studies, including randomized controlled trials, have shown that high-dose riboflavin (usually 400 mg daily) can reduce the frequency and duration of migraine attacks in some individuals. Riboflavin is involved in mitochondrial energy production, and its supplementation is believed to improve mitochondrial dysfunction, a factor implicated in the pathophysiology of migraines. The American Academy of Neurology and the American Headache Society have both recognized riboflavin as "probably effective" for migraine prevention based on available evidence.

It is important to clarify that riboflavin selenite is not a standard form; the commonly studied form is riboflavin (vitamin B2) itself. No credible studies support the use of a riboflavin-selenium combination (selenite) specifically for migraines. The benefit is attributed to riboflavin alone. Overall, the evidence base is moderate to strong, with some systematic reviews and meta-analyses supporting its efficacy and good tolerability in both adults and children. Dosages used in studies are much higher than what is found in standard multivitamins.

In summary, riboflavin is scientifically validated for migraine prophylaxis, with a solid evidence base, but the selenite form is not specifically studied for this condition.

More about Vitamin B2 (riboflavin selenite)
More about Migraine

Other ingredients used for Migraine

5-Hydroxytryptophan (5-HTP)
alpha-linolenic acid (ALA)
ashwagandha
bergamot
beta caryophyllene
black tea
Indian frankincense
bupleurum falcatum
Chinese salvia root
coenzyme Q10 (CoQ10)
turmeric
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
feverfew
fish oil
ginger
ginkgo biloba
gooseberry
gotu kola
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
luteolin
magnesium
melatonin
moringa
niacin (vitamin B3)
omega-3 fatty acids
Peppermint
phytocannabinoids
pine bark
purple butterbur root
riboflavin (vitamin B2)
specialized pro-resolving mediators (SPMs)
Almond fruit
ubiquinol
valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
zinc
atractylodes
blackboard tree
swertia
Szechuan lovage
chrysanthemum
soursop
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
Apple Cider Vinegar
Albizia
Alpha-Lipoic Acid
Atractylone
Betony
Black Seed
Baikal Skullcap
Beta-hydroxybutyrate
Blepharis
Balsam
Banyan
Brahmi
Butterbur
Bifidobacteria
Black Hellebore
Chinese Silkvine
Crocin
Creatine
Cannabidiol
Corydalis
Carthamus
cola nut
Docosahexaenoic Acid
Danshen
Eicosapentaenoic Acid
Folic Acid
Flavin mononucleotide
Ficus religiosa
Fish
Flavanones
Ficus simplicissima
Frankincense
Goldthread
Gelsemium
Ginkgolides
Ginkgoside
Hellebore
iridoids
Ketone Salts
Kuding tea
lemon balm
Lesser speargrass
Little ironweed
Linalool
Mesua
Methylxanthine
Meadowsweet
Nardostachys
Night jessamine
Osthole
Puerarin
Petasines
Phthalides
Paeoniflorin
Pycnogenol
Polygonum
Palmitoylethanolamide (PEA)
Rue
Rubus
Rauvolfia
Rubiaceae
Spikenard
Sensitive Plant
Salmon Oil
Sandalwood
Scabrous Gentian
Uncaria
Withanolides
Xanthine
Xanthophyll
Xanthone
Yuzu
Zingerone

Other health conditions supported by Vitamin B2 (riboflavin selenite)

Cataracts
Dermatitis
Fatigue
Headache (general)
Headache (tension)
Migraine

Products containing Vitamin B2 (riboflavin selenite)

We currently have no products on Vitabase that contain this ingredient.