Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B2, also known as riboflavin, has scientific evidence supporting its use in the prevention of migraines. Multiple randomized controlled trials (RCTs) and meta-analyses have demonstrated that high-dose riboflavin supplementation (typically 400 mg daily) can reduce the frequency and duration of migraine attacks in adults. The proposed mechanism is based on riboflavin’s role as a precursor for flavoproteins involved in mitochondrial energy production. Since impaired mitochondrial function is believed to contribute to migraine pathophysiology, enhancing mitochondrial efficiency with riboflavin may mitigate this trigger.

Key studies include a 1998 double-blind RCT by Schoenen et al., which found a significant reduction in migraine frequency compared to placebo after three months of 400 mg/day riboflavin. Subsequent studies and systematic reviews (e.g., a 2017 review in Journal of Clinical Pharmacy and Therapeutics) have largely supported these findings, though some variability exists in study size and outcomes. Riboflavin is well-tolerated, with minimal side effects, making it a reasonable option for migraine prophylaxis, especially in patients seeking non-pharmacologic interventions.

While riboflavin is not universally effective for all individuals with migraine, and evidence in pediatric populations is less robust, its scientific validation and favorable safety profile justify its use as a preventive strategy for migraines.

More about Vitamin B2 (various)
More about Migraine

Other ingredients used for Migraine

5-Hydroxytryptophan (5-HTP)
alpha-linolenic acid (ALA)
ashwagandha
bergamot
beta caryophyllene
black tea
Indian frankincense
bupleurum falcatum
Chinese salvia root
coenzyme Q10 (CoQ10)
turmeric
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
feverfew
fish oil
ginger
ginkgo biloba
gooseberry
gotu kola
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
luteolin
magnesium
melatonin
moringa
niacin (vitamin B3)
omega-3 fatty acids
Peppermint
phytocannabinoids
pine bark
purple butterbur root
riboflavin (vitamin B2)
specialized pro-resolving mediators (SPMs)
Almond fruit
ubiquinol
valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
zinc
atractylodes
blackboard tree
swertia
Szechuan lovage
chrysanthemum
soursop
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
Apple Cider Vinegar
Albizia
Alpha-Lipoic Acid
Atractylone
Betony
Black Seed
Baikal Skullcap
Beta-hydroxybutyrate
Blepharis
Balsam
Banyan
Brahmi
Butterbur
Bifidobacteria
Black Hellebore
Chinese Silkvine
Crocin
Creatine
Cannabidiol
Corydalis
Carthamus
cola nut
Docosahexaenoic Acid
Danshen
Eicosapentaenoic Acid
Folic Acid
Flavin mononucleotide
Ficus religiosa
Fish
Flavanones
Ficus simplicissima
Frankincense
Goldthread
Gelsemium
Ginkgolides
Ginkgoside
Hellebore
iridoids
Ketone Salts
Kuding tea
lemon balm
Lesser speargrass
Little ironweed
Linalool
Mesua
Methylxanthine
Meadowsweet
Nardostachys
Night jessamine
Osthole
Puerarin
Petasines
Phthalides
Paeoniflorin
Pycnogenol
Polygonum
Palmitoylethanolamide (PEA)
Rue
Rubus
Rauvolfia
Rubiaceae
Spikenard
Sensitive Plant
Salmon Oil
Sandalwood
Scabrous Gentian
Uncaria
Withanolides
Xanthine
Xanthophyll
Xanthone
Yuzu
Zingerone

Other health conditions supported by Vitamin B2 (various)

Anemia
Headache (general)
Migraine
Skin (dry and/or flaky)

Products containing Vitamin B2 (various)

We currently have no products on Vitabase that contain this ingredient.