Evidence supporting the use of: Vitamin B3 (nicotinamide)
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Nicotinamide (a form of Vitamin B3) has some scientific evidence supporting its use for migraine, although the quality and quantity of this evidence is limited. Some small clinical studies and case reports have suggested that Vitamin B3, particularly in the form of nicotinamide or niacin, may help reduce the frequency or severity of migraine attacks. The proposed mechanisms involve vasodilation (widening of blood vessels), modulation of brain energy metabolism, and neuroprotective effects. For example, niacin has been noted anecdotally to abort migraine attacks in some individuals, possibly due to its ability to induce vasodilation. However, most studies are old, small-scale, or lack rigorous controls, and there is no consensus in the neurology community regarding its efficacy. A few pilot studies have indicated that nicotinamide might be beneficial in migraine prevention, but larger, well-designed randomized controlled trials are lacking. Current migraine treatment guidelines do not recommend Vitamin B3 as a standard therapy, and its use is generally considered experimental. While it is sometimes used off-label by integrative or alternative medicine practitioners, this is not based on robust clinical evidence. In summary, while there is a scientific rationale and some preliminary data, the evidence base is weak, and Vitamin B3 is not a mainstream migraine treatment. More research is needed to establish its efficacy and safety for this indication.

More about Vitamin B3 (nicotinamide)
More about Migraine

Other ingredients used for Migraine

5-Hydroxytryptophan (5-HTP)
alpha-linolenic acid (ALA)
ashwagandha
bergamot
beta caryophyllene
black tea
Indian frankincense
bupleurum falcatum
Chinese salvia root
coenzyme Q10 (CoQ10)
turmeric
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
feverfew
fish oil
ginger
ginkgo biloba
gooseberry
gotu kola
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
luteolin
magnesium
melatonin
moringa
niacin (vitamin B3)
omega-3 fatty acids
Peppermint
phytocannabinoids
pine bark
purple butterbur root
riboflavin (vitamin B2)
specialized pro-resolving mediators (SPMs)
Almond fruit
ubiquinol
valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
zinc
atractylodes
blackboard tree
swertia
Szechuan lovage
chrysanthemum
soursop
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
Apple Cider Vinegar
Albizia
Alpha-Lipoic Acid
Atractylone
Betony
Black Seed
Baikal Skullcap
Beta-hydroxybutyrate
Blepharis
Balsam
Banyan
Brahmi
Butterbur
Bifidobacteria
Black Hellebore
Chinese Silkvine
Crocin
Creatine
Cannabidiol
Corydalis
Carthamus
cola nut
Docosahexaenoic Acid
Danshen
Eicosapentaenoic Acid
Folic Acid
Flavin mononucleotide
Ficus religiosa
Fish
Flavanones
Ficus simplicissima
Frankincense
Goldthread
Gelsemium
Ginkgolides
Ginkgoside
Hellebore
iridoids
Ketone Salts
Kuding tea
lemon balm
Lesser speargrass
Little ironweed
Linalool
Mesua
Methylxanthine
Meadowsweet
Nardostachys
Night jessamine
Osthole
Puerarin
Petasines
Phthalides
Paeoniflorin
Pycnogenol
Polygonum
Palmitoylethanolamide (PEA)
Rue
Rubus
Rauvolfia
Rubiaceae
Spikenard
Sensitive Plant
Salmon Oil
Sandalwood
Scabrous Gentian
Uncaria
Withanolides
Xanthine
Xanthophyll
Xanthone
Yuzu
Zingerone

Products containing Vitamin B3 (nicotinamide)

We currently have no products on Vitabase that contain this ingredient.