Evidence supporting the use of: Vitamin B3 (Nicotinamide riboside)
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B3 in the form of nicotinamide riboside (NR) is a precursor to nicotinamide adenine dinucleotide (NAD+), an essential molecule in cellular metabolism and energy production. The rationale for its use in migraine stems from evidence suggesting mitochondrial dysfunction and impaired energy metabolism play roles in migraine pathophysiology. While traditional forms of Vitamin B3, such as niacin and nicotinamide, have been investigated for migraine, NR is a newer, more bioavailable form that has not been as extensively studied in this context.

Some small-scale studies and case reports have suggested that niacin (nicotinic acid) can help alleviate acute migraine attacks, possibly through vasodilation or improved mitochondrial function. However, for NR specifically, clinical evidence is limited. A few pilot studies and preclinical research indicate that boosting NAD+ levels may have neuroprotective effects and could potentially modulate migraine frequency or severity, but high-quality randomized controlled trials are lacking. Thus, while the theoretical basis exists and early research is promising, the current scientific evidence supporting the use of nicotinamide riboside for migraine is weak and preliminary.

In summary, nicotinamide riboside is being investigated for its possible benefits in migraine due to its effects on cellular energy metabolism, but as of now, robust scientific validation is lacking and its use is not standard clinical practice.

More about Vitamin B3 (Nicotinamide riboside)
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Other ingredients used for Migraine

5-Hydroxytryptophan (5-HTP)
alpha-linolenic acid (ALA)
ashwagandha
bergamot
beta caryophyllene
black tea
Indian frankincense
bupleurum falcatum
Chinese salvia root
coenzyme Q10 (CoQ10)
turmeric
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
feverfew
fish oil
ginger
ginkgo biloba
gooseberry
gotu kola
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
luteolin
magnesium
melatonin
moringa
niacin (vitamin B3)
omega-3 fatty acids
Peppermint
phytocannabinoids
pine bark
purple butterbur root
riboflavin (vitamin B2)
specialized pro-resolving mediators (SPMs)
Almond fruit
ubiquinol
valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
zinc
atractylodes
blackboard tree
swertia
Szechuan lovage
chrysanthemum
soursop
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
Apple Cider Vinegar
Albizia
Alpha-Lipoic Acid
Atractylone
Betony
Black Seed
Baikal Skullcap
Beta-hydroxybutyrate
Blepharis
Balsam
Banyan
Brahmi
Butterbur
Bifidobacteria
Black Hellebore
Chinese Silkvine
Crocin
Creatine
Cannabidiol
Corydalis
Carthamus
cola nut
Docosahexaenoic Acid
Danshen
Eicosapentaenoic Acid
Folic Acid
Flavin mononucleotide
Ficus religiosa
Fish
Flavanones
Ficus simplicissima
Frankincense
Goldthread
Gelsemium
Ginkgolides
Ginkgoside
Hellebore
iridoids
Ketone Salts
Kuding tea
lemon balm
Lesser speargrass
Little ironweed
Linalool
Mesua
Methylxanthine
Meadowsweet
Nardostachys
Night jessamine
Osthole
Puerarin
Petasines
Phthalides
Paeoniflorin
Pycnogenol
Polygonum
Palmitoylethanolamide (PEA)
Rue
Rubus
Rauvolfia
Rubiaceae
Spikenard
Sensitive Plant
Salmon Oil
Sandalwood
Scabrous Gentian
Uncaria
Withanolides
Xanthine
Xanthophyll
Xanthone
Yuzu
Zingerone

Products containing Vitamin B3 (Nicotinamide riboside)

We currently have no products on Vitabase that contain this ingredient.