Evidence supporting the use of: Vitamin B3 (Nicotinamide riboside)
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B3 in the form of nicotinamide riboside (NR) is a precursor to nicotinamide adenine dinucleotide (NAD+), an essential molecule in cellular metabolism and energy production. The rationale for its use in migraine stems from evidence suggesting mitochondrial dysfunction and impaired energy metabolism play roles in migraine pathophysiology. While traditional forms of Vitamin B3, such as niacin and nicotinamide, have been investigated for migraine, NR is a newer, more bioavailable form that has not been as extensively studied in this context.

Some small-scale studies and case reports have suggested that niacin (nicotinic acid) can help alleviate acute migraine attacks, possibly through vasodilation or improved mitochondrial function. However, for NR specifically, clinical evidence is limited. A few pilot studies and preclinical research indicate that boosting NAD+ levels may have neuroprotective effects and could potentially modulate migraine frequency or severity, but high-quality randomized controlled trials are lacking. Thus, while the theoretical basis exists and early research is promising, the current scientific evidence supporting the use of nicotinamide riboside for migraine is weak and preliminary.

In summary, nicotinamide riboside is being investigated for its possible benefits in migraine due to its effects on cellular energy metabolism, but as of now, robust scientific validation is lacking and its use is not standard clinical practice.

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