Evidence supporting the use of: Vitamin B6 (Pyridoxine HCl)
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (Pyridoxine HCl) has some scientific support for its use in migraine prevention, but the evidence is limited and not fully conclusive. The rationale for its use is largely based on its role in homocysteine metabolism. Elevated homocysteine levels have been implicated in the pathogenesis of migraines in certain studies. Vitamin B6, often in combination with folic acid and vitamin B12, can help lower homocysteine levels. Several small randomized controlled trials and observational studies have examined the effect of these B vitamins on migraine frequency and severity. Some have found that supplementation reduces migraine frequency, particularly in individuals with the MTHFR gene mutation, which affects homocysteine metabolism. For example, a 2009 randomized, double-blind, placebo-controlled study found that a combination of B6, B12, and folic acid significantly reduced migraine disability and attack frequency in patients with migraine with aura. However, it is unclear how much of this effect is attributable to B6 alone, as most studies have used B vitamins in combination. Guidelines from major headache societies do not currently recommend B6 as a standalone treatment for migraine due to insufficient high-quality evidence. In summary, while there is a plausible biochemical rationale and some clinical evidence supporting the use of vitamin B6 (especially as part of a B-vitamin complex) in migraine prevention, the overall strength of the evidence is modest.

More about Vitamin B6 (Pyridoxine HCl)
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Other ingredients used for Migraine

5-Hydroxytryptophan (5-HTP)
alpha-linolenic acid (ALA)
ashwagandha
bergamot
beta caryophyllene
black tea
Indian frankincense
bupleurum falcatum
Chinese salvia root
coenzyme Q10 (CoQ10)
turmeric
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
feverfew
fish oil
ginger
ginkgo biloba
gooseberry
gotu kola
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
luteolin
magnesium
melatonin
moringa
niacin (vitamin B3)
omega-3 fatty acids
Peppermint
phytocannabinoids
pine bark
purple butterbur root
riboflavin (vitamin B2)
specialized pro-resolving mediators (SPMs)
Almond fruit
ubiquinol
valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
zinc
atractylodes
blackboard tree
swertia
Szechuan lovage
chrysanthemum
soursop
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
Apple Cider Vinegar
Albizia
Alpha-Lipoic Acid
Atractylone
Betony
Black Seed
Baikal Skullcap
Beta-hydroxybutyrate
Blepharis
Balsam
Banyan
Brahmi
Butterbur
Bifidobacteria
Black Hellebore
Chinese Silkvine
Crocin
Creatine
Cannabidiol
Corydalis
Carthamus
cola nut
Docosahexaenoic Acid
Danshen
Eicosapentaenoic Acid
Folic Acid
Flavin mononucleotide
Ficus religiosa
Fish
Flavanones
Ficus simplicissima
Frankincense
Goldthread
Gelsemium
Ginkgolides
Ginkgoside
Hellebore
iridoids
Ketone Salts
Kuding tea
lemon balm
Lesser speargrass
Little ironweed
Linalool
Mesua
Methylxanthine
Meadowsweet
Nardostachys
Night jessamine
Osthole
Puerarin
Petasines
Phthalides
Paeoniflorin
Pycnogenol
Polygonum
Palmitoylethanolamide (PEA)
Rue
Rubus
Rauvolfia
Rubiaceae
Spikenard
Sensitive Plant
Salmon Oil
Sandalwood
Scabrous Gentian
Uncaria
Withanolides
Xanthine
Xanthophyll
Xanthone
Yuzu
Zingerone

Products containing Vitamin B6 (Pyridoxine HCl)

We currently have no products on Vitabase that contain this ingredient.