Evidence supporting the use of: Vitamin E (tocopheryl succinate)
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E, specifically in the form of tocopheryl succinate, has some scientific evidence supporting its use in the management of certain types of migraines, particularly menstrual migraine (also called catamenial migraine). A few small, randomized controlled trials have evaluated the efficacy of Vitamin E supplementation in reducing migraine frequency and severity in women whose migraines are closely related to their menstrual cycle. The proposed mechanism involves Vitamin E's antioxidant properties and its ability to stabilize cell membranes and modulate prostaglandin synthesis, which may be relevant in the pathophysiology of menstrual migraines.

The most frequently cited study is a double-blind, placebo-controlled trial published in 1998, which showed that 400 IU of Vitamin E daily reduced migraine frequency, severity, and associated symptoms in women with menstrual migraine. However, the sample size was small, and the studies have not been widely replicated. There is little evidence for Vitamin E's benefit in migraine outside of this specific subgroup. Guidelines generally do not include Vitamin E as a first-line migraine therapy, and evidence for its use in non-menstrual migraine is lacking.

In summary, while there is modest scientific support for Vitamin E (tocopheryl succinate) in the context of menstrual migraine, the overall evidence base is limited in size and scope, and routine use for all migraine types is not broadly endorsed.

More about Vitamin E (tocopheryl succinate)
More about Migraine

Other ingredients used for Migraine

5-Hydroxytryptophan (5-HTP)
alpha-linolenic acid (ALA)
ashwagandha
bergamot
beta caryophyllene
black tea
Indian frankincense
bupleurum falcatum
Chinese salvia root
coenzyme Q10 (CoQ10)
turmeric
curcumin
DHA (docosahexaenoic acid)
EPA (eicosapentaenoic acid)
feverfew
fish oil
ginger
ginkgo biloba
gooseberry
gotu kola
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
luteolin
magnesium
Melatonin
Moringa
Niacin (vitamin B3)
omega-3 fatty acids
Peppermint
phytocannabinoids
pine bark
purple butterbur root
riboflavin (vitamin B2)
specialized pro-resolving mediators (SPMs)
Almond fruit
ubiquinol
Valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
Zinc
atractylodes
blackboard tree
Swertia
Szechuan lovage
chrysanthemum
soursop
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
apple cider vinegar
Albizia
alpha-lipoic acid
atractylone
betony
black seed
Baikal Skullcap
beta-hydroxybutyrate
Blepharis
balsam
banyan
brahmi
butterbur
Bifidobacteria
Black Hellebore
Chinese silkvine
crocin
creatine
cannabidiol
Corydalis
Carthamus
cola nut
docosahexaenoic Acid
danshen
eicosapentaenoic acid
folic acid
flavin mononucleotide
Ficus religiosa
fish
flavanones
Ficus simplicissima
frankincense
goldthread
Gelsemium
ginkgolides
Ginkgoside
Hellebore
iridoids
ketone salts
kuding tea
lemon balm
Lesser speargrass
little ironweed
linalool
Mesua
Methylxanthine
Meadowsweet
Nardostachys
Night jessamine
Osthole
Puerarin
Petasines
Phthalides
paeoniflorin
Pycnogenol
Polygonum
Palmitoylethanolamide (PEA)
rue
Rubus
Rauvolfia
Rubiaceae
Spikenard
Sensitive Plant
Salmon Oil
Sandalwood
Scabrous Gentian
Uncaria
Withanolides
Xanthine
Xanthophyll
Xanthone
Yuzu
Zingerone

Products containing Vitamin E (tocopheryl succinate)

We currently have no products on Vitabase that contain this ingredient.