Evidence supporting the use of: Vitamin B9
For the health condition: Miscarriage (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B9, also known as folic acid or folate, has scientific validation for its use in supporting the prevention of miscarriage, particularly in the context of preventing neural tube defects and other pregnancy complications. Several studies have shown that folic acid supplementation before conception and during early pregnancy can reduce the risk of neural tube defects, such as spina bifida and anencephaly. While the primary indication for folic acid supplementation is to prevent these congenital anomalies, some research suggests that adequate folate status may be associated with a reduced risk of miscarriage, especially those related to chromosomal abnormalities or impaired placental development. For example, a meta-analysis published in the journal Fertility and Sterility (2016) found that folate supplementation was associated with a modest reduction in the risk of miscarriage. Additionally, folate plays a crucial role in DNA synthesis and repair, which are vital processes in the early stages of embryonic development.

However, it is important to note that while folic acid supplementation is widely recommended for all women of childbearing age to prevent neural tube defects, the evidence supporting its direct effectiveness in preventing all types of miscarriage (including those unrelated to neural tube defects) is less robust. The overall quality of evidence suggests a benefit, but it is not definitive for all cases of miscarriage. Therefore, folic acid is justified scientifically, with moderate evidence for its use in miscarriage prevention.

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