Evidence supporting the use of: Vitamin B9 (calcium methyltetrahydrofolate)
For the health condition: Miscarriage (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B9, particularly in the form of calcium methyltetrahydrofolate (a bioactive, methylated form of folate), is scientifically validated for its importance in pregnancy, mainly in reducing the risk of neural tube defects. There is moderate evidence suggesting that adequate folate status may reduce the risk of miscarriage, though its primary indication is not specifically miscarriage prevention. Several studies have observed that women with low folate levels or hyperhomocysteinemia (elevated homocysteine due to poor folate metabolism) have a higher risk of adverse pregnancy outcomes, including miscarriage. Folate is crucial for DNA synthesis, repair, methylation, and cellular division—all vital during early embryonic development. Its deficiency can result in impaired placental development or abnormal fetal growth, potentially contributing to miscarriage.

Some observational studies and meta-analyses have suggested that women who supplement with folic acid or methylated folate before and during early pregnancy have a lower risk of miscarriage compared to those who do not. However, randomized controlled trials explicitly demonstrating a direct reduction in miscarriage rates are limited, and the evidence is not as strong as it is for prevention of neural tube defects. Thus, while scientific rationale and some supportive evidence exist, folate supplementation is more robustly recommended for overall pregnancy health and neural tube defect prevention, with miscarriage risk reduction being a possible but less definitively proven benefit.

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