Evidence supporting the use of: Vitamin B9 (Mixed)
For the health condition: Miscarriage (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B9, also known as folate or folic acid (when in synthetic form), has scientific backing for its use in reproductive health, particularly for the prevention of neural tube defects in developing fetuses. While its primary indication is not specifically miscarriage prevention, there is moderate scientific evidence that adequate folate status before and during early pregnancy may reduce the risk of miscarriage. Folate is essential for DNA synthesis, repair, and methylation, all of which are critical during periods of rapid cell division and growth, such as embryogenesis.

Several observational studies have suggested that women with low folate levels or those not taking folic acid supplements are at increased risk for spontaneous abortion. A large prospective cohort study published in 2012 (Gaskins et al., Am J Clin Nutr) found that higher folate intake was associated with a reduced risk of miscarriage. However, the evidence is not uniformly strong, and randomized controlled trials specifically targeting miscarriage prevention are limited. Most guidelines recommend folic acid supplementation to prevent neural tube defects rather than miscarriage per se, although the overlap in timing (periconceptional period) means folate is frequently used in women at risk of miscarriage.

In summary, while scientific evidence exists for a potential protective effect of Vitamin B9 against miscarriage, the evidence is moderate and somewhat indirect. The strongest and most widely accepted use remains neural tube defect prevention, with miscarriage reduction as a possible secondary benefit.

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