Synopsis

Source of validity: Scientific
Rating (out of 5): 2

3,5-Diiodothyronine (3,5-T2) is an endogenous thyroid hormone metabolite. It has garnered scientific interest due to its effects on energy metabolism, particularly at the mitochondrial level. Several preclinical studies, primarily in animal models, demonstrate that 3,5-T2 can stimulate mitochondrial respiration, increase oxygen consumption, and improve fatty acid oxidation. These effects are thought to arise from its ability to enhance the activity of mitochondrial enzymes and uncouple oxidative phosphorylation, resulting in increased energy expenditure and decreased fat accumulation without the thyrotoxic side effects associated with more potent thyroid hormones like T3 or T4.

However, evidence in humans is currently limited. Most of the data supporting its use come from rodent studies, where 3,5-T2 administration led to improvements in parameters such as insulin sensitivity and lipid metabolism, suggesting a beneficial role in metabolic disorders. Some in vitro studies using human cells have shown increased mitochondrial activity in response to 3,5-T2, but robust human clinical trials are lacking.

Therefore, while there is a scientific rationale and promising preclinical evidence for 3,5-Diiodothyronine’s role in supporting mitochondrial function, the current level of evidence is modest (rated 2 out of 5), and its use in humans for this purpose remains experimental and not clinically established.

More about 3,5 Diiodothyronine
More about Mitochondria

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acetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
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caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
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AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
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Alpha polylactate
Apigenin
Alpha-Lipoic Acid
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adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
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Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
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Creatine
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Other body systems supported by 3,5 Diiodothyronine

Mitochondria

Products containing 3,5 Diiodothyronine

We currently have no products on Vitabase that contain this ingredient.