Evidence supporting the use of: Acetyl l-carnitine
For the body system: Mitochondria

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Acetyl L-carnitine (ALCAR) is a naturally occurring derivative of L-carnitine, which plays a crucial role in mitochondrial energy metabolism. Specifically, ALCAR facilitates the transport of long-chain fatty acids into the mitochondria, where they are oxidized ("burned") to produce energy. Several clinical and preclinical studies have explored ALCAR's potential to support mitochondrial function, particularly in the context of neurodegenerative diseases and age-related cognitive decline. Evidence suggests that ALCAR may enhance mitochondrial energy production, reduce oxidative stress, and improve mitochondrial dynamics, especially in neuronal tissues. For example, research in animal models and in some small human trials indicates that ALCAR supplementation can increase mitochondrial activity and may confer neuroprotective effects in conditions such as Alzheimer's disease and mild cognitive impairment. However, while results are promising, large-scale, high-quality randomized controlled trials in humans are limited, and findings are not entirely consistent across all studies. Thus, while there is a reasonable scientific rationale and moderate empirical support for the use of acetyl L-carnitine to support mitochondrial function, more robust clinical evidence is needed to fully validate its efficacy for the general population.

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