Evidence supporting the use of: Acetyl L-Carnitine Arginate
For the body system: Mitochondria

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Acetyl L-Carnitine Arginate is a compound that combines Acetyl L-Carnitine (ALCAR) with the amino acid arginine. Most scientific attention has focused on ALCAR, an acetylated form of L-carnitine, which plays a critical role in mitochondrial energy metabolism by facilitating the transport of fatty acids into the mitochondria for β-oxidation and energy production. Multiple animal and human studies indicate that ALCAR supplementation can enhance mitochondrial function, reduce oxidative stress, and may even support cognitive function, particularly in aging populations. For example, research published in journals such as Neurochemistry International and Proceedings of the National Academy of Sciences has shown that ALCAR can improve mitochondrial bioenergetics and protect against mitochondrial dysfunction.

The addition of arginine as an arginate salt is thought to potentially provide further support by increasing nitric oxide production, which could enhance blood flow and nutrient delivery to tissues, though direct studies on the combination are limited.

Overall, while the evidence for ALCAR's role in supporting mitochondrial health is robust and consistent, direct research on the Acetyl L-Carnitine Arginate compound is sparse. Thus, the evidence rating reflects strong support for ALCAR but only a moderate evidence base for the specific arginate form and its additional benefits for the mitochondrial system.

More about Acetyl L-Carnitine Arginate
More about Mitochondria

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Other body systems supported by Acetyl L-Carnitine Arginate

Brain
Circulatory System
Heart
Mitochondria
Muscles
Nerves

Products containing Acetyl L-Carnitine Arginate

We currently have no products on Vitabase that contain this ingredient.