Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Alpha-lipoic acid (ALA) is a naturally occurring compound that acts as a cofactor for mitochondrial enzyme complexes, particularly those involved in energy metabolism such as the pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase complexes. Its scientific use for mitochondrial support is based on both its direct role in mitochondrial energy production and its potent antioxidant properties. ALA can scavenge reactive oxygen species and regenerate other antioxidants, such as vitamins C and E, thereby protecting mitochondrial components from oxidative damage.

Multiple preclinical studies have demonstrated that ALA supplementation improves mitochondrial function, increases ATP production, and reduces oxidative stress in various tissues. In animal models of mitochondrial dysfunction and aging, ALA has been shown to restore mitochondrial enzyme activities and enhance mitochondrial biogenesis. Human clinical studies, though fewer, suggest potential benefits in conditions characterized by mitochondrial impairment, such as diabetic neuropathy and some neurodegenerative diseases. However, while mechanistic and animal data are robust, large-scale clinical trials directly targeting mitochondrial disorders in humans are limited.

Overall, the evidence supporting the use of ALA for mitochondrial support is substantial from a mechanistic and preclinical standpoint, with emerging but still limited clinical validation. It is widely used in integrative medicine for this purpose, supported by its biochemical role and antioxidant effects.

More about alpha-lipoic acid
More about Mitochondria

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adenosine 5-triphosphate disodium (ATP)
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alpha-ketoglutarate (AKG)
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animal protein
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caffeic Acid
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capsinoids
cardarine
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catechins
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cistanche
citicoline
cocarboxylase
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coenzyme Q10 (CoQ10)
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copper
creatine
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epigallocatechin gallate (EGCG)
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flavin mononucleotide
flavones
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fucoxanthin
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Other body systems supported by alpha-lipoic acid

Arteries
Blood
Brain
Circulatory System
Heart
Hepatic System
Liver
Mitochondria
Nerves
Skin

Products containing alpha-lipoic acid

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