Evidence supporting the use of: Alpha polylactate
For the body system: Mitochondria
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Alpha polylactate is a proprietary form of lactate (often bound to minerals such as calcium, magnesium, or sodium) that has been explored for its effects on exercise performance and mitochondrial support. The rationale for its use is based on the role of lactate as an energy substrate. During exercise, lactate can be shuttled to mitochondria, where it is converted to pyruvate and further metabolized in the Krebs cycle, contributing to ATP production. Some studies, including those on products like E-Caps' "Sustained Energy," suggest that alpha polylactate may enhance endurance by providing a more readily available fuel source and potentially buffering lactic acid buildup. However, direct evidence supporting alpha polylactate as a specific "mitochondrial support" supplement in humans is limited. Most research focuses on exercise performance rather than direct mitochondrial enhancement. While the theoretical basis exists—since mitochondria metabolize lactate—the clinical significance and translation to improved mitochondrial function in non-athletic populations remain unclear. No major clinical trials have established alpha polylactate as a definitive mitochondrial booster. Overall, the evidence for its use in "mitochondrial support" is modest and mainly extrapolated from its role in exercise metabolism rather than direct mitochondrial outcomes.
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alpha-lipoic acid
amino acids
AMP-activated protein kinase (AMPK)
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apigenin
ashitaba
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beta-hydroxybutyrate
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bovine liver
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caffeic Acid
caffeine
Camellia sinensis
capsiate
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cardarine
cardiolipin
catechins
centrophenoxine
chocolate
cistanche
citicoline
cocarboxylase
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fucoxanthin
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thyroid substance
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