Evidence supporting the use of: Apigenin
For the body system: Mitochondria
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Apigenin is a flavonoid found in various plants such as parsley, chamomile, and celery. There is emerging scientific interest in its potential to support mitochondrial function, primarily based on preclinical studies. Several in vitro and animal studies have demonstrated that apigenin may exert antioxidant effects, reduce mitochondrial oxidative stress, and enhance mitochondrial biogenesis. For example, research in cultured cells has shown that apigenin can upregulate proteins involved in mitochondrial function, such as PGC-1α, and may help protect mitochondria from damage induced by toxins or oxidative stress. Additionally, animal models suggest that apigenin supplementation can mitigate mitochondrial dysfunction in conditions like neurodegeneration and metabolic syndrome.
However, human clinical data specifically linking apigenin supplementation to improved mitochondrial health are lacking. Most of the current evidence is limited to laboratory and animal research, with limited translational relevance or direct application to human health. As such, while the mechanistic studies provide a rationale for further investigation, the evidence supporting apigenin as a mitochondrial support supplement in humans remains preliminary. Therefore, the current scientific evidence can be considered weak to moderate (rated 2 out of 5), pending more rigorous human trials.
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alpha-ketoglutarate (AKG)
alpha-lipoic acid
amino acids
AMP-activated protein kinase (AMPK)
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animal protein
apigenin
ashitaba
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beta-hydroxybutyrate
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bovine liver
C-phycocyanin
caffeic Acid
caffeine
Camellia sinensis
capsiate
capsinoids
cardarine
cardiolipin
catechins
centrophenoxine
chocolate
cistanche
citicoline
cocarboxylase
Coenzyme A
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine
creatine monohydrate
cyanidin
d-alpha tocopherol
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dihydrolipoic acid
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fucoxanthin
fulvic acid
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luteolin
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