Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Beta-hydroxybutyrate (BHB) is a ketone body produced naturally in the liver during periods of low carbohydrate intake, prolonged exercise, or fasting. Scientific studies suggest that BHB can support mitochondrial function in several ways. Firstly, BHB serves as an efficient alternative energy substrate for mitochondria, especially in the brain and muscles, when glucose availability is limited. Research indicates that BHB metabolism generates fewer reactive oxygen species (ROS) compared to glucose metabolism, potentially reducing oxidative stress on mitochondria (Newman & Verdin, 2017). Additionally, BHB has been shown to upregulate genes involved in mitochondrial biogenesis and function via histone deacetylase (HDAC) inhibition, leading to enhanced cellular energy production and resilience (Shimazu et al., 2013). Animal and cellular studies have demonstrated that BHB supplementation may improve mitochondrial respiration and protect against mitochondrial dysfunction in neurodegenerative and metabolic disorders. While most evidence comes from preclinical models, early human trials and mechanistic studies support the plausibility of BHB's beneficial effects on mitochondrial health. However, large-scale human clinical trials are still limited. Overall, the scientific basis for BHB's support of the mitochondrial body system is strong, but ongoing research is needed to fully establish efficacy and optimal use in humans.

More about Beta-hydroxybutyrate
More about Mitochondria

Other ingredients that support Mitochondria

7-Keto-DHEA
acetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
glucose
Ketone Salts

Other body systems supported by Beta-hydroxybutyrate

Blood
Brain
Heart
Immune System
Mitochondria
Muscles

Products containing Beta-hydroxybutyrate

We currently have no products on Vitabase that contain this ingredient.