Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Capsinoids are non-pungent compounds found in certain types of chili peppers, structurally similar to capsaicin. Their use in supporting mitochondrial function has some scientific basis, although research is still emerging. Several animal and human studies indicate that capsinoids can increase energy expenditure and promote fat oxidation, effects linked to enhanced mitochondrial activity. For example, studies have demonstrated that capsinoids activate transient receptor potential vanilloid 1 (TRPV1) receptors, leading to increased thermogenesis and upregulation of genes associated with mitochondrial biogenesis such as PGC-1α. Some human clinical trials have shown modest increases in metabolic rate and reductions in body fat with capsinoid supplementation, suggesting improved mitochondrial efficiency in energy metabolism.

However, most evidence comes from short-term studies, and the effects are generally mild. The direct impact on mitochondrial function, rather than overall energy expenditure or fat oxidation, has not been thoroughly delineated in clinical settings. Nevertheless, the mechanistic links—such as TRPV1 activation and increased expression of mitochondrial genes—provide plausible support for the role of capsinoids in mitochondrial health. Overall, while there is scientific validation for capsinoids influencing processes related to mitochondrial function, the strength of evidence is moderate, and more robust, long-term human trials are needed to confirm these effects.

More about Capsinoids
More about Mitochondria

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adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
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greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
L-carnosine
L-citrulline
L-glutathione
L-glycine
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lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
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manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
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niacin (vitamin B3)
niacinamide (Vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic compounds
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
schisandra chinensis
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
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ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
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vitamin D3
water
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thyroid substance
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Alpha polylactate
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Ampelopsin
Adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
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Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
Flavin mononucleotide
Fish
Fatty acids
Fungus
Fucoxanthin
Flavones
Ginsenosides
Gamma-Glutamylcysteine
glucose
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Guanidinopropionic Acid (GPA )
Geranylgeraniol
Haematococcus pluvialis
Honokiol
inosine
Idebenone
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methoxy-substituted benzoquinones
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NADH
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Other body systems supported by Capsinoids

Arteries
Blood
Circulatory System
Digestive System
Mitochondria
Stomach

Products containing Capsinoids

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