Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Cardarine (GW501516) is a peroxisome proliferator-activated receptor delta (PPAR-δ) agonist, initially developed for its potential to treat metabolic and cardiovascular diseases. Its relevance to mitochondrial function comes from its ability to enhance the expression of genes involved in fatty acid oxidation and energy metabolism, particularly in muscle tissue. Preclinical studies in rodents have shown that Cardarine increases mitochondrial biogenesis and improves mitochondrial efficiency, leading to improved exercise endurance and lipid metabolism (Narkar et al., 2008). These effects are mediated by upregulation of pathways that enhance oxidative metabolism, mimicking some aspects of endurance exercise at the cellular level. However, most of the evidence for these mitochondrial benefits comes from animal studies and cell culture models. Few, if any, robust clinical trials in humans have confirmed these effects or established their safety profile. Cardarine’s development for clinical use was halted due to concerns about carcinogenicity observed in long-term animal trials. Nevertheless, its mitochondrial effects are scientifically plausible and supported by mechanistic data, though human relevance and safety remain unproven. Therefore, while there is scientific basis for Cardarine’s support of mitochondrial function, the evidence is incomplete and not clinically validated.

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Other ingredients that support Mitochondria

1,3,7-Trimethylpurine-2,6-dione
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7-Keto-DHEA
Acetyl L-carnitine
adenosine 5-triphosphate disodium (ATP)
Adenosine triphosphate (ATP)
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Alpha polylactate
alpha-ketoglutarate (AKG)
alpha-lipoic acid
amino acids
AMP-activated protein kinase (AMPK)
ampelopsin
animal protein
apigenin
ashitaba
ashwagandha
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berry
beta-hydroxybutyrate
black ginger
bovine liver
C-phycocyanin
caffeic Acid
caffeine
Camellia sinensis
capsiate
capsinoids
cardarine
cardiolipin
catechins
centrophenoxine
chocolate
cistanche
citicoline
cocarboxylase
Coenzyme A
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine
creatine monohydrate
cyanidin
d-alpha tocopherol
D-Ribose
dihydrolipoic acid
electrolytes blend (proprietary)
epigallocatechin gallate (EGCG)
ergothioneine
eriocitrin
fatty acids
fisetin
fish
fish oil
flavin mononucleotide
flavones
flavonols
fruit and vegetable blend (proprietary)
fucoxanthin
fulvic acid
fungus
gamma-glutamylcysteine
ganoderma
geranylgeraniol
Ginsenosides
glucose
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glycerophosphocholine (GPC)
goji berry
gooseberry
grape
greens blend (proprietary)
guanidinopropionic acid (GPA )
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herbal blend (proprietary)
hesperetin
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Idebenone
inosine
Kaempferide
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ketone salts
knotweed
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l-carnitine
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L-glutathione
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nicotinamide riboside
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oleanolic acid
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oxaloacetic acid
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pantethine
pantothenic acid (vitamin B5)
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phosphatidylcholine
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ribose
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Rosarin
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Salidroside
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selenium
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succinic acid
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thyroid substance
tocotrienols
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Trans-geranylgeraniol
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tributyrin
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ubiquinol
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Other body systems supported by cardarine

Mitochondria
Muscles

Products containing cardarine

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