Cocarboxylase, also known as thiamine pyrophosphate (TPP), is the active coenzyme form of vitamin B1 (thiamine). Its use to support the mitochondrial body system is scientifically justified by its essential role in mitochondrial metabolism. Cocarboxylase functions as a cofactor for several key enzymes involved in the mitochondrial citric acid (Krebs) cycle and the pentose phosphate pathway, including pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, and transketolase. These enzymes are critical for oxidative phosphorylation and ATP production, the primary energy-generating processes in mitochondria.

Deficiency in thiamine (and thus, in cocarboxylase) impairs mitochondrial energy metabolism, leading to various clinical manifestations including neurological and cardiovascular disorders. Scientific studies, including in vitro, animal, and clinical research, have demonstrated that supplementation with thiamine or its active forms can restore mitochondrial function in deficiency states. For example, thiamine supplementation is recognized in the management of disorders like Wernicke’s encephalopathy and beriberi, both of which involve mitochondrial dysfunction due to thiamine deficiency.

While direct supplementation with cocarboxylase (as opposed to thiamine) is less common, the mechanistic understanding of its mitochondrial role is robust. Therefore, there is substantial scientific evidence supporting the use of cocarboxylase to optimize mitochondrial energy metabolism, especially in cases of deficiency or increased metabolic demand.