Evidence supporting the use of: Coffee fruit
For the body system: Mitochondria

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Coffee fruit, also known as coffee cherry, is the fruit surrounding the coffee bean. Recent scientific interest has focused on its potential neuroprotective and mitochondrial benefits due to its rich content of polyphenols, including chlorogenic acids and other antioxidants. Studies suggest that coffee fruit extract may increase levels of brain-derived neurotrophic factor (BDNF), a protein associated with mitochondrial health and cognitive function. However, most of the evidence is preliminary and comes from in vitro studies, animal models, or small-scale human trials. There is some indication that antioxidant compounds in coffee fruit could help combat oxidative stress, which is a key factor in mitochondrial dysfunction. Nevertheless, direct evidence linking coffee fruit consumption to improved mitochondrial function in humans remains limited. The bulk of human research has focused on cognitive or neurotrophic outcomes rather than direct mitochondrial measures. In summary, there is a scientific rationale for the use of coffee fruit to support mitochondrial health based on its antioxidant profile and effects on BDNF, but robust clinical evidence is currently lacking, resulting in a moderate evidence rating.

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capsinoids
cardarine
cardiolipin
catechins
centrophenoxine
chocolate
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citicoline
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Other body systems supported by coffee fruit

Brain
Mitochondria