Evidence supporting the use of: CoQ10
For the body system: Mitochondria
Synopsis
Source of validity: Scientific
Rating (out of 5): 4
Coenzyme Q10 (CoQ10) is scientifically justified for supporting mitochondrial function. CoQ10 is a lipid-soluble molecule present in virtually all cell membranes, but it is especially concentrated in the mitochondria, where it plays a central role in the electron transport chain (ETC). The ETC is essential for aerobic cellular respiration and the production of adenosine triphosphate (ATP), the cell’s main energy currency. CoQ10 acts as an electron carrier, shuttling electrons between complexes within the mitochondrial membrane, which is critical for efficient ATP synthesis.
Multiple studies have shown that CoQ10 levels decline with age and in certain disease states associated with mitochondrial dysfunction, such as heart failure, neurodegenerative diseases (e.g., Parkinson’s disease), and mitochondrial myopathies. Supplementing with CoQ10 has been demonstrated in randomized controlled trials to improve markers of mitochondrial function and, in some cases, clinical outcomes, particularly in heart failure and some mitochondrial disorders.
While not all research shows dramatic effects, and the benefits may depend on the underlying condition, the biochemical role of CoQ10 in mitochondrial energy production is well established. Thus, the use of CoQ10 as a mitochondrial support supplement is grounded in both fundamental biochemistry and clinical research, meriting a relatively high evidence rating.
Other ingredients that support Mitochondria
7-Keto-DHEAacetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
Flavin mononucleotide
Fish
Fatty acids
Flavones
glucose
Ketone Salts
Other body systems supported by CoQ10
ArteriesBlood
Brain
Circulatory System
Heart
Mitochondria
Muscles
Nerves
Reproductive System
Skin