DHA-conjugated phosphatidylserine (PS-DHA) is a phospholipid complex in which docosahexaenoic acid (DHA), an omega-3 fatty acid, is attached to phosphatidylserine (PS), a key phospholipid found in mitochondrial and neuronal membranes. The use of PS-DHA to support mitochondrial function is supported by a moderate level of scientific evidence, primarily from in vitro studies, animal models, and limited human data.

Mitochondria rely on membrane integrity and the availability of specific phospholipids, particularly PS and DHA, for optimal function, including energy production, apoptosis regulation, and oxidative stress response. Research indicates that both PS and DHA individually enhance mitochondrial membrane fluidity, support electron transport, and protect against oxidative damage. PS is a critical component for mitochondrial membrane structure and function, while DHA is a major fatty acid in mitochondrial membranes, especially in neural tissue, where it is essential for bioenergetics and resilience to stress.

Animal studies (e.g., J Nutr Biochem, 2015; Front Aging Neurosci, 2018) suggest that PS-DHA supplementation improves mitochondrial dynamics and energy metabolism, particularly in the brain. Human data are limited but indicate potential cognitive and neuroprotective benefits, which are believed to be mediated in part by improved mitochondrial function. However, large-scale clinical trials specifically examining mitochondrial endpoints are lacking, so while the biological rationale is strong and preclinical data are supportive, direct human evidence remains modest.