Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Dihydrolipoic acid (DHLA) is the reduced form of alpha-lipoic acid (ALA), a naturally occurring compound that plays a critical role in mitochondrial energy metabolism. Both ALA and DHLA function as cofactors for mitochondrial enzyme complexes, particularly the pyruvate dehydrogenase and α-ketoglutarate dehydrogenase complexes, which are vital for the Krebs cycle and ATP production. Scientific studies have demonstrated that DHLA, like ALA, acts as a potent antioxidant, protecting mitochondrial membranes and enzymes from oxidative stress, a factor implicated in mitochondrial dysfunction and aging.

Research supports that DHLA can regenerate other antioxidants, such as vitamins C and E, and increase cellular glutathione levels, further contributing to mitochondrial protection. Experimental models (cellular and animal) show that supplementation with ALA/DHLA can improve mitochondrial function, reduce oxidative damage, and enhance energy metabolism. However, most clinical studies have focused on ALA supplementation; DHLA is less stable and less studied in human trials, but its effects are presumed similar due to its close relationship and rapid interconversion with ALA in vivo.

Overall, the use of dihydrolipoic acid to support mitochondrial function is supported by a mechanistic scientific rationale and preclinical evidence, with moderate support from clinical studies (mostly using ALA). Therefore, its evidence rating is moderate (3/5).

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Other body systems supported by dihydrolipoic acid

Blood
Brain
Circulatory System
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Products containing dihydrolipoic acid

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