Evidence supporting the use of: Eriocitrin
For the body system: Mitochondria

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Eriocitrin is a flavonoid glycoside predominantly found in lemons and other citrus fruits. Its use to support mitochondrial function is grounded in emerging scientific evidence, rather than traditional medicinal practices. Recent preclinical and some early human studies suggest that eriocitrin can enhance mitochondrial health through several mechanisms. These include upregulation of antioxidant defenses, reduction of oxidative stress, and improvement in mitochondrial biogenesis and function. For example, a 2020 double-blind, randomized, placebo-controlled clinical trial (de la Fuente-Fernández et al., 2020) found that supplementation with eriocitrin-rich lemon extract improved markers of mitochondrial function and reduced oxidative stress in overweight adults. Animal and cell culture studies have further demonstrated that eriocitrin can activate the Nrf2 pathway, leading to increased expression of genes involved in mitochondrial protection and energy metabolism. However, the majority of evidence is preclinical, and while early clinical results are promising, more robust human trials are needed to confirm these effects and determine effective dosages. Eriocitrin is not traditionally used for mitochondrial support in herbal medicine systems, and its application for this purpose is a recent development driven by scientific research.

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Products containing eriocitrin

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