Evidence supporting the use of: Fatty acids
For the body system: Mitochondria

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Fatty acids, particularly omega-3 polyunsaturated fatty acids (PUFAs) such as EPA and DHA, have scientific evidence supporting their role in mitochondrial function. Mitochondria are the energy-producing organelles in cells, and fatty acids are one of their primary fuel sources, especially in tissues with high energy demands like the heart and muscles. Research shows that long-chain fatty acids are not only metabolized by mitochondria to produce ATP, but they also affect mitochondrial biogenesis, membrane fluidity, and the regulation of oxidative stress. For example, studies indicate that omega-3 fatty acids can increase the expression of genes involved in mitochondrial biogenesis (e.g., PGC-1α), enhance mitochondrial respiration efficiency, and reduce excessive production of reactive oxygen species (ROS), thereby protecting mitochondrial integrity. Clinical and preclinical studies have suggested that supplementation with omega-3 fatty acids may improve mitochondrial function in conditions like metabolic syndrome, neurodegenerative disorders, and aging. While the majority of evidence stems from animal and cellular models, human studies are increasingly confirming these effects, though more large-scale trials are needed. Thus, the use of fatty acids to support mitochondrial health is grounded in a solid mechanistic foundation and growing clinical evidence.

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Products containing Fatty acids

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